FIGURE 2. MITF maps to the epicentre of an amplicon present in a subset of malignant melanomas.
From the following article:
Levi A. Garraway, Hans R. Widlund, Mark A. Rubin, Gad Getz, Aaron J. Berger, Sridhar Ramaswamy, Rameen Beroukhim, Danny A. Milner, Scott R. Granter, Jinyan Du, Charles Lee, Stephan N. Wagner, Cheng Li, Todd R. Golub, David L. Rimm, Matthew L. Meyerson, David E. Fisher and William R. Sellers
Nature 436, 117-122(7 July 2005)
doi:10.1038/nature03664
a, Quantitative PCR analysis of the MITF locus across 62 benign nevi, primary and metastatic melanomas. Cases with MITF amplification are shaded black. b, Transcript map of the core 3p13–3p14 amplicon present within the MALME-3M cell line. The FOXP1 gene resides outside the core amplicon. c, Quantitative PCR analysis of several genes within the amplicon (see Methods for details). MALME-3M and SK-MEL-5 are NCI60 cell lines with and without the amplicon, respectively. IM1 and IM3 are primary melanoma samples; MM4, MM5 and nr 99/2 are metastatic melanoma samples. TMF1, UBE1C, GRSP1, LOC391543 and FOXP1 are genes flanking MITF.
