FIGURE 1. Increased MITF expression associated with chromosome 3p amplification in melanoma cell lines.
From the following article:
Levi A. Garraway, Hans R. Widlund, Mark A. Rubin, Gad Getz, Aaron J. Berger, Sridhar Ramaswamy, Rameen Beroukhim, Danny A. Milner, Scott R. Granter, Jinyan Du, Charles Lee, Stephan N. Wagner, Cheng Li, Todd R. Golub, David L. Rimm, Matthew L. Meyerson, David E. Fisher and William R. Sellers
Nature 436, 117-122(7 July 2005)
doi:10.1038/nature03664
a, Schematic of the integrated genomic approach (see text). b, Hierarchical clustering of raw copy-number data from NCI60 cell lines and normal diploid controls shows cell line subclusters (coloured rectangles, top) and the corresponding chromosome specific SNP clusters (right). CNS, central nervous system tumour; NSCLC, non-small-cell lung cancer. c, Integration of copy-number and gene-expression data. Shown are colourgrams of SNP copy number at 3p14–3p12 (top) and the significant gene-expression correlates from chromosome 3 following supervised analysis (bottom). d, Chromosome 3 copy-number values (top), SNP signal intensity colourgram (middle), cytoband map (bottom), significant genes (arrows), and the MALME-3M core amplicon (red box) are shown.
