Editor's Summary

7 July 2005

Kinome truths

A genome-wide analysis of the human kinome — the sum total of protein, lipid and carbohydrate kinases — shows that the cell's signalling functions are intimately linked to endocytosis, the process by which material is imported into the cell inside a membrane vesicle. Many of the kinases involved in endocytosis are known to function in mitogenic signalling, stimulating cell division and lymphocyte transformation: this adds to growing evidence that endocytic transport and signal transduction are integrated processes. An accompanying manuscript looks at the role of some of the kinases identified in the kinome screen, revealing novel dynamic properties of caveola/raft-mediated endocytosis that are distinct from the current picture of membrane transport.

Article: Genome-wide analysis of human kinases in clathrin- and caveolae/raft-mediated endocytosis

Lucas Pelkmans, Eugenio Fava, Hannes Grabner, Michael Hannus, Bianca Habermann, Eberhard Krausz and Marino Zerial

doi:10.1038/nature03571

Abstract | Full Text | PDF (1,406K) | Supplementary information

Letter: Kinase-regulated quantal assemblies and kiss-and-run recycling of caveolae

Lucas Pelkmans and Marino Zerial

doi:10.1038/nature03866

First paragraph | Full Text | PDF (719K) | Supplementary information