Supplementary information
From the following article:
Somatic mosaicism in neuronal precursor cells mediated by L1 retrotransposition
Alysson R. Muotri, Vi T. Chu, Maria C. N. Marchetto, Wei Deng, John V. Moran and Fred H. Gage
Nature 435, 903-910 (16 June 2005)
doi:10.1038/nature03663
Supplementary Data
Structures of L1 derived retrotransposition events in single cell clones from rat neural progenitor cells transfected with the L1-EGFP reporter construct (Word; 188 KB).
Supplementary Figure Legends
Legends to accompany the below Supplementary Figures
Supplementary Methods
Detailed, additional methods information to accompany the main manuscript.
Supplementary Notes
Description of some neuronal genes targeted by L1 retrotransposition in neuronal precursor cells.
Supplementary Tables S1 and S2
These tables resume the cloning survival after CCg-treatment and the transcripts obtained from the CCg-array experiment, respectively.
Supplementary Video
This movie shows the neuronal differentiation of the Cl 22. The time lapse covers a period of 41h, during witch time the EGFP from the insertion site (Psd-93 gene) expression is turned on.
Supplementary Figure S1
L1 transcripts are enriched in CCg-responsive cells.
Supplementary Figure S2
Luciferase controls for the L1 5'UTR promoter analyses.
Supplementary Figure S3
Adult NPCs derived from rat brain support L1 retrotransposition. FACS analysis.
Supplementary Figure S4
Chromatin modification is associated with L1 insertion silencing.
Supplementary Figure S5
Embryonic analysis of the L1-EGFP transgenic mice. Pregnant females were sacrificed at E10.5 and embryos were removed by micro-dissection.
Supplementary Figure S6
Detection of L1 retrotransposition in other tissues of the L1-EGFP transgenic mice.
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