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Nature 435, 898-899 (16 June 2005) | doi:10.1038/435898a; Published online 15 June 2005
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Senior Statistical Genetics in High-throughput Sequencing Analysis
- University of Oxford
- Oxford United Kingdom
Postdoctoral Fellow - Computational Genomics - Team 78 – Ref: 80464
- Wellcome Trust Sanger Institute
- Hinxton, Cambridgeshire CB10 1, UK
Developmental biology: One source for muscle
Iain W. McKinnell1 & Michael A. Rudnicki1
Abstract
Producing muscle as an embryo, and making or repairing it as an adult, could be considered to be quite different processes. But it seems that cells that share a common origin carry out both of these tasks.
The generation and repair of skeletal muscle is a highly ordered, multi-step process that requires many progenitor cells and continues throughout embryonic, fetal and postnatal life. In this issue, Gros et al.page 954)1 and Relaix et al.page 948)2 show that a common progenitor cell not only maintains muscle growth during late embryonic development, but also seems to be the origin of the satellite cells responsible for postnatal muscle growth and repair.
- Iain W. McKinnell and Michael A. Rudnicki are at the Ottawa Health Research Institute, 501 Smyth Road, Ottawa, Ontario K1H 8L6, Canada.
Email: mrudnicki@ohri.ca
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RESEARCH
A common somitic origin for embryonic muscle progenitors and satellite cellsNature Letters to Editor (16 Jun 2005)
A Pax3/Pax7-dependent population of skeletal muscle progenitor cellsNature Letters to Editor (16 Jun 2005)
Functional skeletal muscle regeneration from differentiating embryonic stem cellsNature Medicine Article (01 Feb 2008)
See all 5 matches for Research