Table of contents
Volume 435 Number 7043 pp713-854
Editorials
All or nothing at Fermilab p713
These days, it takes a brave laboratory to hitch its future to the construction of a brand-new particle accelerator — but Fermilab has elected to do just that.
doi: 10.1038/435713a
Kyoto — the sequel p713
Better knowledge of the carbon cycle could provide a basis for future climate-change agreements.
doi: 10.1038/435713b
Talent worth nurturing p714
More should be done to draw people with disabilities into scientific careers.
doi: 10.1038/435714a
News
Chemistry society goes head to head with NIH in fight over public database p718
Free molecule registry triggers the wrath of a larger, fee-based effort.
Emma Marris
doi: 10.1038/435718a
One in three scientists confesses to having sinned p718
Misconduct ranges from faking results outright to dropping suspect data points.
Meredith Wadman
doi: 10.1038/435718b
Blue Brain boots up to mixed response p720
Swiss supercomputer faces brainy task of modelling neural circuits.
Jim Giles
doi: 10.1038/435720a
Europe halts decisions on stem-cell patents p720
Ethical concerns put applications on hold indefinitely.
Sonja Schubert
doi: 10.1038/435720b
Soap opera reaps prize for its clean message p723
Radio programme entertains but also educates about sustainable farming practices.
Jessica Ebert
doi: 10.1038/435723a
Snapshot: Sunlight on an icy martian crater p723
First three-dimensional colour image reveals a frozen wonder.
doi: 10.1038/435723b
Sidelines p724
doi: 10.1038/435724a
Pall hangs over desert's future as alien weeds fuel wildfires p724
Invasive species add to fire risk in Sonoran ecosystem.
Quirin Schiermeier
doi: 10.1038/435724b
Evolutionist row makes museum ditch donation p725
But intelligent-design group will show movie on Smithsonian premises.
Geoff Brumfiel
doi: 10.1038/435725a
News in brief p726
doi: 10.1038/435726a
Correction p726
doi: 10.1038/435726b
News Features
Fermilab: High-risk physics p728
In the world of billion-dollar particle physics, one lab is taking an enormous gamble on its future. Geoff Brumfiel takes a look at Fermilab's hopes to host the next big machine.
doi: 10.1038/435728a
See also: Editor's summary
Space physiology: Lie back and think of science p730
Twelve women have taken to bed for two months in the name of space research. Nicola Jones joins them for a few days, and asks what physiologists hope to learn from this marathon lie-in.
doi: 10.1038/435730a
Climate change: That sinking feeling p732
Siberia's vast forests absorb huge quantities of carbon from the atmosphere. But how much, and will they continue to do so in a warming world? Quirin Schiermeier speaks to the carbon accountants.
doi: 10.1038/435732a
Business
Touched by an angel p734
Looking for a fairy godmother to back a brilliant business idea? As Tony Reichhardt reports, a group of them probably meets for breakfast once a month at a hotel near you.
Tony Reichhardt
doi: 10.1038/435734a
In brief p735
doi: 10.1038/435735a
Market watch p735
doi: 10.1038/435735b
Correspondence
Controls on exports will defend security, without harming labs p736
Peter Lichtenbaum
doi: 10.1038/435736a
Veracity of raw images can also come into question p736
Jeremy Adler
doi: 10.1038/435736b
Academic boycott would damage chances for peace p736
John R. Cohn
doi: 10.1038/435736c
A boycott could do good in Israel, as in South Africa p736
Rita Giacaman, Jacqueline Sfeir and Ismat al-Shakhshir
doi: 10.1038/435736d
Commentary
Scientists behaving badly p737
To protect the integrity of science, we must look beyond falsification, fabrication and plagiarism, to a wider range of questionable research practices, argue Brian C. Martinson, Melissa S. Anderson and Raymond de Vries.
doi: 10.1038/435737a
See also: Editor's summary
Books and Arts
Born to greatness? p739
Staking a claim in history for one of the driving forces behind quantum mechanics.
Kurt Gottfried reviews The End of the Certain World: The Life and Science of Max Born by Nancy Thorndike Greenspan
doi: 10.1038/435739a
Acting on instinct p740
Johan J. Bolhuis reviews Patterns of Behavior: Konrad Lorenz, Niko Tinbergen, and the Founding of Ethology by Richard W. Burkhardt, Jr
doi: 10.1038/435740a
Dance: Einstein in motion p741
Alison Wright reviews
doi: 10.1038/435741a
Essay
Physics, complexity and causality p743
Although the laws of physics explain much of the world around us, we still do not have a realistic description of causality in truly complex hierarchical structures.
George F. R. Ellis
doi: 10.1038/435743a
See also: Editor's summary
News and Views
Cancer genomics: Small RNAs with big impacts p745
Although they are tiny, microRNAs can have large-scale effects because they regulate a variety of genes. These minuscule molecules are now definitively linked to the development of cancer.
Paul S. Meltzer
doi: 10.1038/435745a
See also: Editor's summary
Organic chemistry: Fast reactions 'on water' p746
Efficient reactions in aqueous organic chemistry do not require soluble reactants, as had been thought. A newly developed 'on-water' protocol is characterized by short reaction times, and the products are easy to isolate.
Jaap E. Klijn and Jan B. F. N. Engberts
doi: 10.1038/435746a
Structural biology: Prying into prions p747
Various aberrant protein forms are the subject of intense research. It is not easy to probe their structures, but studies that have done so provide telling information about their biological properties.
Christopher M. Dobson
doi: 10.1038/435747a
See also: Editor's summary
50 and 100 years ago p748
doi: 10.1038/435748a
Planetary science: Shades of Titan p749
Instruments aboard the Cassini spacecraft can 'see' through the dense atmosphere of Titan, Saturn's largest moon. Returned images hint at the existence of features such as ridges and valleys, and perhaps an icy volcano.
Louise Prockter
doi: 10.1038/435749a
See also: Editor's summary
Plant−fungal associations: Cue for the branching connection p750
Plant roots release potent molecules that activate symbiotic fungi and initiate a harmonious relationship. It turns out that the same compounds are detected by parasitic weeds for less benign purposes.
Martin Parniske
doi: 10.1038/435750a
See also: Editor's summary
Computational science: Can get satisfaction p751
The sheer complexity of some computational problems means they will probably never be solved, despite the ever-increasing resources available. But we can sometimes predict under what conditions solutions exist.
Carla P. Gomes and Bart Selman
doi: 10.1038/435751a
See also: Editor's summary
Cancer: Inflammation by remote control p752
Smouldering beneath many latent tumours is a chronic inflammation that goads pre-malignant cells into becoming full-blown cancer. The spark that kindles these flames comes from an unexpected source.
Alberto Mantovani
doi: 10.1038/435752a
Brief Communications
Brevetoxicosis: Red tides and marine mammal mortalities p755
Unexpected brevetoxin vectors may account for deaths long after or remote from an algal bloom.
Leanne J. Flewelling, Jerome P. Naar, Jay P. Abbott, Daniel G. Baden, Nélio B. Barros, Gregory D. Bossart, Marie-Yasmine D. Bottein, Daniel G. Hammond, Elsa M. Haubold, Cynthia A. Heil, Michael S. Henry, Henry M. Jacocks, Tod A. Leighfield, Richard H. Pierce, Thomas D. Pitchford, Sentiel A. Rommel, Paula S. Scott, Karen A. Steidinger, Earnest W. Truby, Frances M. Van Dolah and Jan H. Landsberg
doi: 10.1038/nature435755a
First paragraph | Full Text | PDF (266K) | Supplementary information
See also: Editor's summary
Seismology: Earthquake risk on the Sunda trench p756
Suleyman S. Nalbant, Sandy Steacy, Kerry Sieh, Danny Natawidjaja and John McCloskey
doi: 10.1038/nature435756a
First paragraph | Full Text | PDF (302K)
See also: Editor's summary
Plant biochemistry: Anthocyanin biosynthesis in roses p757
Jun Ogata, Yoshiaki Kanno, Yoshio Itoh, Hidehito Tsugawa and Masahiko Suzuki
doi: 10.1038/nature435757a
First paragraph | Full Text | PDF (255K) | Supplementary information
Articles
Rigorous location of phase transitions in hard optimization problems p759
Dimitris Achlioptas, Assaf Naor and Yuval Peres
doi: 10.1038/nature03602
Abstract | Full Text | PDF (221K)
See also: Editor's summary | News and Views by Gomes & Selman
Structural insights into a yeast prion illuminate nucleation and strain diversity p765
Rajaraman Krishnan and Susan L. Lindquist
doi: 10.1038/nature03679
Abstract | Full Text | PDF (466K) | Supplementary information
See also: Editor's summary | News and Views by Dobson
Structure of the cross-
spine of amyloid-like fibrils p773
Rebecca Nelson, Michael R. Sawaya, Melinda Balbirnie, Anders Ø. Madsen, Christian Riekel, Robert Grothe and David Eisenberg
doi: 10.1038/nature03680
Abstract | Full Text | PDF (310K) | Supplementary information
See also: Editor's summary | News and Views by Dobson
The structure of the myosin VI motor reveals the mechanism of directionality reversal p779
Julie Ménétrey, Amel Bahloul, Amber L. Wells, Christopher M. Yengo, Carl A. Morris, H. Lee Sweeney and Anne Houdusse
doi: 10.1038/nature03592
Abstract | Full Text | PDF (566K) | Supplementary information
See also: Editor's summary
Letters
Release of volatiles from a possible cryovolcano from near-infrared imaging of Titan p786
C. Sotin, R. Jaumann, B. J. Buratti, R. H. Brown, R. N. Clark, L. A. Soderblom, K. H. Baines, G. Bellucci, J.-P. Bibring, F. Capaccioni, P. Cerroni, M. Combes, A. Coradini, D. P. Cruikshank, P. Drossart, V. Formisano, Y. Langevin, D. L. Matson, T. B. McCord, R. M. Nelson, P. D. Nicholson, B. Sicardy, S. LeMouelic, S. Rodriguez, K. Stephan and C. K. Scholz
doi: 10.1038/nature03596
First paragraph | Full Text | PDF (291K)
See also: Editor's summary | News and Views by Prockter
Discovery of an aurora on Mars p790
Jean-Loup Bertaux, François Leblanc, Olivier Witasse, Eric Quemerais, Jean Lilensten, S. A. Stern, B. Sandel and Oleg Korablev
doi: 10.1038/nature03603
First paragraph | Full Text | PDF (385K)
See also: Editor's summary
A thermally self-sustained micro solid-oxide fuel-cell stack with high power density p795
Zongping Shao, Sossina M. Haile, Jeongmin Ahn, Paul D. Ronney, Zhongliang Zhan and Scott A. Barnett
doi: 10.1038/nature03673
First paragraph | Full Text | PDF (413K) | Supplementary information
See also: Editor's summary
Lightning-induced intensification of the ionospheric sporadic E layer p799
C. J. Davis and C. G. Johnson
doi: 10.1038/nature03638
First paragraph | Full Text | PDF (216K)
See also: Editor's summary
Geomagnetic dipole strength and reversal rate over the past two million years p802
Jean-Pierre Valet, Laure Meynadier and Yohan Guyodo
doi: 10.1038/nature03674
First paragraph | Full Text | PDF (707K)
Effects of species and functional group loss on island ecosystem properties p806
David A. Wardle and Olle Zackrisson
doi: 10.1038/nature03611
First paragraph | Full Text | PDF (246K) | Supplementary information
See also: Editor's summary
Average remaining lifetimes can increase as human populations age p811
Warren C. Sanderson and Sergei Scherbov
doi: 10.1038/nature03593
First paragraph | Full Text | PDF (248K) | Supplementary information
See also: Editor's summary
Uncovering the overlapping community structure of complex networks in nature and society p814
Gergely Palla, Imre Derényi, Illés Farkas and Tamás Vicsek
doi: 10.1038/nature03607
First paragraph | Full Text | PDF (496K) | Supplementary information
See also: Editor's summary
Nitrogen transfer in the arbuscular mycorrhizal symbiosis p819
Manjula Govindarajulu, Philip E. Pfeffer, Hairu Jin, Jehad Abubaker, David D. Douds, James W. Allen, Heike Bücking, Peter J. Lammers and Yair Shachar-Hill
doi: 10.1038/nature03610
First paragraph | Full Text | PDF (228K)
See also: Editor's summary
Plant sesquiterpenes induce hyphal branching in arbuscular mycorrhizal fungi p824
Kohki Akiyama, Ken-ichi Matsuzaki and Hideo Hayashi
doi: 10.1038/nature03608
First paragraph | Full Text | PDF (246K) | Supplementary information
See also: Editor's summary | News and Views by Parniske
A microRNA polycistron as a potential human oncogene p828
Lin He, J. Michael Thomson, Michael T. Hemann, Eva Hernando-Monge, David Mu, Summer Goodson, Scott Powers, Carlos Cordon-Cardo, Scott W. Lowe, Gregory J. Hannon and Scott M. Hammond
doi: 10.1038/nature03552
First paragraph | Full Text | PDF (460K) | Supplementary information
See also: Editor's summary | News and Views by Meltzer
MicroRNA expression profiles classify human cancers p834
Jun Lu, Gad Getz, Eric A. Miska, Ezequiel Alvarez-Saavedra, Justin Lamb, David Peck, Alejandro Sweet-Cordero, Benjamin L. Ebert, Raymond H. Mak, Adolfo A. Ferrando, James R. Downing, Tyler Jacks, H. Robert Horvitz and Todd R. Golub
doi: 10.1038/nature03702
First paragraph | Full Text | PDF (293K) | Supplementary information
See also: Editor's summary | News and Views by Meltzer
c-Myc-regulated microRNAs modulate E2F1 expression p839
Kathryn A. O'Donnell, Erik A. Wentzel, Karen I. Zeller, Chi V. Dang and Joshua T. Mendell
doi: 10.1038/nature03677
First paragraph | Full Text | PDF (339K) | Supplementary information
See also: Editor's summary | News and Views by Meltzer
Correlation of structural elements and infectivity of the HET-s prion p844
Christiane Ritter, Marie-Lise Maddelein, Ansgar B. Siemer, Thorsten Lührs, Matthias Ernst, Beat H. Meier, Sven J. Saupe and Roland Riek
doi: 10.1038/nature03793
First paragraph | Full Text | PDF (936K) | Supplementary information
See also: Editor's summary | News and Views by Dobson
Naturejobs
ProspectFrench lessons p849
New postdoc award promotes collaboration between North American and French biotech
Paul Smaglik
doi: 10.1038/nj7043-849a
Postdocs and Students
Getting schooled p850
To juggle teaching and research, classroom veterans advise beginners to draw on mentors and all the resources they can find. Kendall Powell learns about the balancing act.
Kendall Powell
doi: 10.1038/nj7043-850a
Futures
Looking for Mr Goodbug p854
Will work for food.
Elisabeth Malartre
doi: 10.1038/435854a
