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Nature 435, 752-753 (9 June 2005) | doi:10.1038/435752a; Published online 8 June 2005
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Senior Executive- Finance Corporate Office
- Rhydburg Pharmaceuticals
- Selaqui-Dehradun India
Dermapathologist
- Indiana University School of Medicine
- Indiana, USA
Cancer: Inflammation by remote control
Alberto Mantovani1
Abstract
Smouldering beneath many latent tumours is a chronic inflammation that goads pre-malignant cells into becoming full-blown cancer. The spark that kindles these flames comes from an unexpected source.
Chronic inflammation makes individuals susceptible to many forms of cancer. The culprits that drive this process are inflammatory cells and signalling molecules of the 'innate' immune system — our in-born defence system, which recognizes potential threats without previous exposure to them.
- Alberto Mantovani is at the Istituto Mario Negri, Via Eritrea 62, 20157 Milan, and the ICH University of Milan, Milan, Italy.
Email: mantovani@marionegri.it
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