FIGURE 1. MicroRNA expression profiling of P493-6 cells with high and low c-Myc expression.

From the following article:

c-Myc-regulated microRNAs modulate E2F1 expression

Kathryn A. O'Donnell, Erik A. Wentzel, Karen I. Zeller, Chi V. Dang and Joshua T. Mendell

Nature 435, 839-843(9 June 2005)

doi:10.1038/nature03677

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a, Western blot analysis of c-Myc in untreated cells or in cells treated with tetracycline (Tet). Blots were stripped and reprobed for alpha-tubulin to demonstrate equal loading of samples. b, MicroRNA expression arrays hybridized with RNA from tet-treated (+ Tet) or untreated (- Tet) cells. Magnified panels show miRNAs that were consistently upregulated in the high c-Myc state. A probe complementary to threonine tRNA (tRNAThr) served as a control for equal hybridization.

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