Table of contents
Volume 435 Number 7042 pp537-712
Editorials
An auspicious victory p537
A vote by the US House of Representatives to ease restrictions on embryonic stem-cell research marks an important turning point — whether President Bush vetoes the change or not.
doi: 10.1038/435537a
Seeds in threatened soil p537
US hostility towards Syria is undermining the stability of an important seed bank for dry areas.
doi: 10.1038/435537b
Too much, too soon p538
How not to promote your latest research findings in the media.
doi: 10.1038/435538a
News
Flu in wild birds sparks fears of mutating virus p542
Experts pressure China for samples that can be analysed.
David Cyranoski
doi: 10.1038/435542a
UK research councils claim success for open-access publishing plan p543
Papers based on funded research will be posted on free websites.
Jim Giles
doi: 10.1038/435543a
Special report: Back in the race p544
An almost unthinkable defeat for President Bush in Congress has put embryonic stem-cell research firmly back on the US agenda. But with South Korea setting a pace the United States will still struggle to match, the field's future is fraught. Nature reports on the key political battles surrounding this issue.
Erika Check
doi: 10.1038/435544a
Protein structures hint at the shape of things to come p547
Consortium rapidly unravels dozens of structure puzzles.
Alison Abbott
doi: 10.1038/435547a
Sidelines p547
doi: 10.1038/435547b
Drug giants fail to name compounds in trial database p548
Critics charge that negative results are deliberately obscured.
Meredith Wadman
doi: 10.1038/435548b
Yeast feeds debate on prolonging life p548
Fruitflies grow older when certain foods are cut.
Carina Dennis
doi: 10.1038/nature03861
US treasury seeks bright ideas to beat bogus dollars p549
Technology helps counterfeiters but may also hinder them.
Emma Marris
doi: 10.1038/435549a
News Features
Scientists with disabilities: Access all areas p552
Scientific research can be tricky at the best of times, but people with disabilities face additional challenges both in the lab and when dealing with data. Jessica Ebert meets the researchers who are building their own customized solutions to overcome these problems.
doi: 10.1038/435552a
Molecular medicine: Lost in translation p556
A mysterious disease that causes children's brains to melt away is caused by errors in RNA translation. But biologists are realizing that this horrifying condition could shed light on more common problems. Claire Ainsworth reports.
doi: 10.1038/435556a
See also: Editor's summary
Business
More flavour up front p559
Emma Marris
doi: 10.1038/435559a
See also: Editor's summary
In brief p559
doi: 10.1038/435559b
Correspondence
Technology managers do their bit for world health p561
Ashley J. Stevens
doi: 10.1038/435561a
Ampicillin threat leads to wider transgene concern p561
Gundula Azeez
doi: 10.1038/435561b
Activists should accept mainstream view of GM p561
David T. Dennis
doi: 10.1038/435561c
Commentary
A fresh start for Europe's space agency p563
The European Space Agency has a strong track record and plenty of ambition to propel it into its next 30 years, says Giovanni Bignami. But key decisions must be made in the context of a new Europe.
doi: 10.1038/435563a
See also: Editor's summary
Books and Arts
Expanding evolution p565
A broader view of inheritance puts pressure on the neo-darwinian synthesis.
Massimo Pigliucci reviews Evolution in Four Dimensions: Genetic, Epigenetic, Behavioral, and Symbolic Variation in the History of Life by Eva Jablonka and Marion J. Lamb
doi: 10.1038/435565a
Death and taxas p566
Norman Myers reviews Insect Diversity Conservation by Michael J. Samways
doi: 10.1038/435566a
Taking a tip from the past p567
John Carmody reviews Poison Arrows: The Amazing Story of How Prozac and Anaesthetics Were Developed From Deadly Jungle Poison Darts by Stanley Feldman
doi: 10.1038/435567a
Essay
ConceptThe best solution p569
Optimization: this beguilingly simply idea allows biologists not only to understand current adaptations, but also to predict new designs that may yet evolve.
William J. Sutherland
doi: 10.1038/435569a
See also: Editor's summary
News and Views
Human behaviour: Brain trust p571
As is the case with other social interactions, financial transactions depend on trust. That fact is behind ingenious experiments that explore the neurobiological underpinnings of human behaviour.
Antonio Damasio
doi: 10.1038/435571a
See also: Editor's summary
Cosmology: Digitizing the Universe p572
For years, cosmologists have been racing each other to develop ever more sophisticated and realistic models of the evolution of the Universe. The competition has just become considerably stiffer.
Nickolay Y. Gnedin
doi: 10.1038/435572a
See also: Editor's summary
Stem cells: The road not taken p573
Developmental 'road maps' chart the steps from simple cells to mature, specialized cells. A newly discovered variety of blood-cell progenitor doesn't fit into the accepted blood map, but should that map be redrawn?
Hanno Hock and Stuart H. Orkin
doi: 10.1038/435573a
Molecular electronics: Charged with manipulation p575
The ability to control charge transport through individual molecules sandwiched between electrodes could lead to further miniaturization of electronics. A better understanding of how such junctions work is crucial.
Mark Ratner
doi: 10.1038/435575a
50 and 100 years ago p576
doi: 10.1038/435576a
Gene therapy: The moving finger p577
DNA-cleaving enzymes trigger a repair process that can now be harnessed to correct mutations in the human genome in vitro. This represents another step towards gene-correction strategies for treating human disease.
Katherine A. High
doi: 10.1038/435577a
See also: Editor's summary
Analytical chemistry: The Renaissance palette p577
Richard Webb
doi: 10.1038/435577b
Gene regulation: Kissing chromosomes p579
A three-dimensional examination of gene regulation suggests that portions from different chromosomes 'communicate' with each other, and bring related genes together in the nucleus to coordinate their expression.
Dimitris Kioussis
doi: 10.1038/435579a
See also: Editor's summary
Brief Communications
Extraterrestrial meteors: A martian meteor and its parent comet p581
An image of an extraterrestrial meteor was captured as a strange streak in the sky over Mars last year.
Franck Selsis, Mark T. Lemmon, Jérémie Vaubaillon and James F. Bell, III
doi: 10.1038/435581a
First paragraph | Full Text | PDF (147K)
See also: Editor's summary
Insight: Autoimmunity - Free access
Produced with support from:
Insight: Autoimmunity
Autoimmunity p583
Elaine Bell and Lucy Bird
doi: 10.1038/435583a
Paths to understanding the genetic basis of autoimmune disease p584
John D. Rioux and Abul K. Abbas
doi: 10.1038/nature03723
Abstract | Full Text | PDF (294K)
Cellular and genetic mechanisms of self tolerance and autoimmunity p590
Christopher C. Goodnow, Jonathon Sprent, Barbara Fazekas de St Groth and Carola G. Vinuesa
doi: 10.1038/nature03724
Abstract | Full Text | PDF (4,189K)
Regulation of immunity by self-reactive T cells p598
Mitchell Kronenberg and Alexander Rudensky
doi: 10.1038/nature03725
Abstract | Full Text | PDF (1,330K)
An array of possibilities for the study of autoimmunity p605
C. Garrison Fathman, Luis Soares, Steven M. Chan and Paul J. Utz
doi: 10.1038/nature03726
Abstract | Full Text | PDF (588K)
Design of effective immunotherapy for human autoimmunity p612
Marc Feldmann and Lawrence Steinman
doi: 10.1038/nature03727
Abstract | Full Text | PDF (1,375K)
Treatment of severe autoimmune disease by stem-cell transplantation p620
Megan Sykes and Boris Nikolic
doi: 10.1038/nature03728
Abstract | Full Text | PDF (3,493K)
Articles
Simulations of the formation, evolution and clustering of galaxies and quasars p629
Volker Springel, Simon D. M. White, Adrian Jenkins, Carlos S. Frenk, Naoki Yoshida, Liang Gao, Julio Navarro, Robert Thacker, Darren Croton, John Helly, John A. Peacock, Shaun Cole, Peter Thomas, Hugh Couchman, August Evrard, Jörg Colberg and Frazer Pearce
doi: 10.1038/nature03597
Abstract | Full Text | PDF (442K) | Supplementary information
See also: Editor's summary | News and Views by Gnedin
Interchromosomal associations between alternatively expressed loci p637
Charalampos G. Spilianakis, Maria D. Lalioti, Terrence Town, Gap Ryol Lee and Richard A. Flavell
doi: 10.1038/nature03574
Abstract | Full Text | PDF (607K) | Supplementary information
See also: Editor's summary | News and Views by Kioussis
Highly efficient endogenous human gene correction using designed zinc-finger nucleases p646
Fyodor D. Urnov, Jeffrey C. Miller, Ya-Li Lee, Christian M. Beausejour, Jeremy M. Rock, Sheldon Augustus, Andrew C. Jamieson, Matthew H. Porteus, Philip D. Gregory and Michael C. Holmes
doi: 10.1038/nature03556
Abstract | Full Text | PDF (522K) | Supplementary information
See also: Editor's summary | News and Views by High
Letters
A resolved outflow of matter from a brown dwarf p652
Emma T. Whelan, Thomas P. Ray, Francesca Bacciotti, Antonella Natta, Leonardo Testi and Sofia Randich
doi: 10.1038/nature03598
First paragraph | Full Text | PDF (172K) | Supplementary information
See also: Editor's summary
Ultrafast non-thermal control of magnetization by instantaneous photomagnetic pulses p655
A. V. Kimel, A. Kirilyuk, P. A. Usachev, R. V. Pisarev, A. M. Balbashov and Th. Rasing
doi: 10.1038/nature03564
First paragraph | Full Text | PDF (821K)
See also: Editor's summary
Field regulation of single-molecule conductivity by a charged surface atom p658
Paul G. Piva, Gino A. DiLabio, Jason L. Pitters, Janik Zikovsky, Moh'd Rezeq, Stanislav Dogel, Werner A. Hofer and Robert A. Wolkow
doi: 10.1038/nature03563
First paragraph | Full Text | PDF (337K)
See also: News and Views by Ratner
Arctic freshwater forcing of the Younger Dryas cold reversal p662
Lev Tarasov and W.R. Peltier
doi: 10.1038/nature03617
First paragraph | Full Text | PDF (223K) | Supplementary information
See also: Editor's summary
Seismological constraints on a possible plume root at the core−mantle boundary p666
Sebastian Rost, Edward J. Garnero, Quentin Williams and Michael Manga
doi: 10.1038/nature03620
First paragraph | Full Text | PDF (885K) | Supplementary information
Discovery of a short-necked sauropod dinosaur from the Late Jurassic period of Patagonia p670
Oliver W. M. Rauhut, Kristian Remes, Regina Fechner, Gerardo Cladera and Pablo Puerta
doi: 10.1038/nature03623
First paragraph | Full Text | PDF (246K) | Supplementary information
See also: Editor's summary
Oxytocin increases trust in humans p673
Michael Kosfeld, Markus Heinrichs, Paul J. Zak, Urs Fischbacher and Ernst Fehr
doi: 10.1038/nature03701
First paragraph | Full Text | PDF (170K)
See also: News and Views by Damasio
An inhibitor of Bcl-2 family proteins induces regression of solid tumours p677
Tilman Oltersdorf, Steven W. Elmore, Alexander R. Shoemaker, Robert C. Armstrong, David J. Augeri, Barbara A. Belli, Milan Bruncko, Thomas L. Deckwerth, Jurgen Dinges, Philip J. Hajduk, Mary K. Joseph, Shinichi Kitada, Stanley J. Korsmeyer, Aaron R. Kunzer, Anthony Letai, Chi Li, Michael J. Mitten, David G. Nettesheim, ShiChung Ng, Paul M. Nimmer, Jacqueline M. O'Connor, Anatol Oleksijew, Andrew M. Petros, John C. Reed, Wang Shen, Stephen K. Tahir, Craig B. Thompson, Kevin J. Tomaselli, Baole Wang, Michael D. Wendt, Haichao Zhang, Stephen W. Fesik and Saul H. Rosenberg
doi: 10.1038/nature03579
First paragraph | Full Text | PDF (362K) | Supplementary information
See also: Editor's summary
SV40-encoded microRNAs regulate viral gene expression and reduce susceptibility to cytotoxic T cells p682
Christopher S. Sullivan, Adam T. Grundhoff, Satvir Tevethia, James M. Pipas and Don Ganem
doi: 10.1038/nature03576
First paragraph | Full Text | PDF (372K) | Supplementary information
See also: Editor's summary
Insights into E3 ligase activity revealed by a SUMO−RanGAP1−Ubc9−Nup358 complex p687
David Reverter and Christopher D. Lima
doi: 10.1038/nature03588
First paragraph | Full Text | PDF (533K) | Supplementary information
Structural basis for nuclear import complex dissociation by RanGTP p693
Soo Jae Lee, Yoshiyuki Matsuura, Sai Man Liu and Murray Stewart
doi: 10.1038/nature03578
First paragraph | Full Text | PDF (256K) | Supplementary information
Structure of oxidized 
-haemoglobin bound to AHSP reveals a protective mechanism for haem p697
Liang Feng, Suiping Zhou, Lichuan Gu, David A. Gell, Joel P. Mackay, Mitchell J. Weiss, Andrew J. Gow and Yigong Shi
doi: 10.1038/nature03609
First paragraph | Full Text | PDF (388K) | Supplementary information
See also: Editor's summary
Structural characterization of the molecular platform for type III secretion system assembly p702
Calvin K. Yip, Tyler G. Kimbrough, Heather B. Felise, Marija Vuckovic, Nikhil A. Thomas, Richard A. Pfuetzner, Elizabeth A. Frey, B. Brett Finlay, Samuel I. Miller and Natalie C. J. Strynadka
doi: 10.1038/nature03554
First paragraph | Full Text | PDF (540K) | Supplementary information
Naturejobs
ProspectMaking a move on mobility p709
Grass roots organization seeks more mobility data for Europe
Paul Smaglik
doi:10.1038/nj7042-709a
Futures
Dial M for middleware p712
Dirty work down on the Pharm.
David Hall
doi: 10.1038/435712a
