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Nature 435, 579-580 (2 June 2005) | doi:10.1038/435579a; Published online 1 June 2005

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Gene regulation:  Kissing chromosomes

Dimitris Kioussis1

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A three-dimensional examination of gene regulation suggests that portions from different chromosomes 'communicate' with each other, and bring related genes together in the nucleus to coordinate their expression.

The cell has evolved many strategies to orchestrate gene activation or repression. Spilianakis et al.1 (page 637 of this issue) reveal a novel mechanism of gene regulation, throwing light on how cells organize their genome to respond efficiently to stimuli.

  1. Dimitris Kioussis is in the Division of Molecular Immunology, National Institute for Medical Research, The Ridgeway, London NW7 1AA, UK.
    Email: dkioussis@nimr.mrc.ac.uk

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