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Nature 435, 573-575 (2 June 2005) | doi:10.1038/435573a; Published online 1 June 2005
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Stem cells: The road not taken
Hanno Hock1 & Stuart H. Orkin1
Abstract
Developmental 'road maps' chart the steps from simple cells to mature, specialized cells. A newly discovered variety of blood-cell progenitor doesn't fit into the accepted blood map, but should that map be redrawn?
The diverse specialized cell types of the body are all derived from comparatively rare, immature cells known as stem cells. This process is almost always represented by hierarchy diagrams, in which cells are depicted making orderly decisions, progressively restricting their developmental options with each step.
- Hanno Hock and Stuart H. Orkin are at the Children's Hospital and Dana-Farber Cancer Institute, Harvard Medical School and Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA.
Email: stuart_orkin@dfci.harvard.edu
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