Supplementary information

From the following article:

A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity

Carola G. Vinuesa, Matthew C. Cook, Constanza Angelucci, Vicki Athanasopoulos, Lixin Rui, Kim M. Hill, Di Yu, Heather Domaschenz, Belinda Whittle, Teresa Lambe, Ian S. Roberts, Richard R. Copley, John I. Bell, Richard J. Cornall & Christopher C. Goodnow

Nature 435, 452-458(26 May 2005)

doi:10.1038/nature03555

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Supplementary Figures S1-S12

This file contains 12 Supplementary Figures that provide detailed characterization of the incidence, female:male bias and gene dose effects of the sanroque phenotype including ANAs, Ig titres, glomerulonephritis, flow cytometric analysis of all lymphoid compartments, immunohistology of splenic germinal centres, response to immunization and known tolerance pathways. Mapping and genotyping details of the sanroque mutation and Roquin mRNA expression are also provided, together with the full Roquin preotein sequence and phylogenetic conservation.

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Supplementary Figures Legends

This file contains a brief description for each of the 12 Supplementary Figures.

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Supplementary Methods

Details of the Supplementary Methods used for Flow cytometry, CFSE labelling, and immunohistology.

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Supplementary Data

This file contains the microarray data referred to in the paper in MIAME-compliant format and a completed MIAME checklist.

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