Editorials

On a wing and a prayer p385

This issue's focus on avian flu highlights progress and incoherence in the world's response to a potential human pandemic. But the threat is enormous, and some priorities are clear enough.

doi: 10.1038/435385a

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Europe's constitution p386

Referenda next week could derail the European project — with negative consequences for science.

doi: 10.1038/435386a

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Chemical biology is here p386

Nature and its new sibling Nature Chemical Biology reflect an important multidisciplinary trend.

doi: 10.1038/435386b

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Research Highlights

Research highlights p388

doi: 10.1038/435388a

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News

Bird flu spreads among Java's pigs p390

Indonesian government scrambles to track disease.

David Cyranoski

doi: 10.1038/435390a

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Ecologist's tenure hailed as triumph for academic freedom p390

Decision caps years of free-speech challenges.

Rex Dalton

doi: 10.1038/435390b

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UK panel urges animal researchers to go public p392

Scientific openness may defuse general disapproval.

Jim Giles

doi: 10.1038/435392a

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Korea's accelerating stem-cell work prompts calls for global ethical rules p393

Breakthrough highlights differences among countries.

Erika Check

doi: 10.1038/435393a

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Zambia to wage 'scientific' war on malaria p395

Foundation pledges results within a few years.

Declan Butler

doi: 10.1038/435395a

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Sidelines p396

doi: 10.1038/435396a

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We'll rain on your parade, forecasters tell rogue pundits p396

Independent weather companies answer to no one.

Jim Giles

doi: 10.1038/435396b

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NIH hints at ethics rule change p397

Owning biomedical stock may not be a problem after all.

Emma Marris

doi: 10.1038/435397a

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News in brief p398

doi: 10.1038/435398a

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News Features

Avian flu special:  Avian flu: Are we ready? p399

doi: 10.1038/435399a

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Avian flu special:  The flu pandemic: were we ready? p400

Welcome to my weblog. I'm Sally O'Reilly, a freelance journalist based in Washington DC. I've been researching a book on pandemic preparedness. But now the time for preparation has run out.

doi: 10.1038/435400a

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Avian flu special:  Is this our best shot? p404

We have the means to make a vaccine against pandemic flu. But quarrels over money, science and politics mean it could come too late, says Erika Check.

doi: 10.1038/435404a

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Avian flu special:  What's in the medicine cabinet? p407

Drugs that could lessen the death toll in a flu pandemic do exist. But global stockpiles are too small, and the countries at most immediate risk are among the worst prepared. Alison Abbott reports.

doi: 10.1038/435407a

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Business

Wall Street's gradual green revolution p410

Companies and investors are starting to wake up to the powerful impact that global warming could have on their bottom line. Emma Marris reports.

doi: 10.1038/435410a

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In brief p411

doi: 10.1038/435411a

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Market watch p411

doi: 10.1038/435411b

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Correspondence

Scientists need back-up by climate organizations p413

Christian Körner, Heinz Wanner and Christoph Ritz

doi: 10.1038/435413a

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Love of nature led Beuys to new artistic language p413

Pete Jeffs

doi: 10.1038/435413b

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Head of Lorenz Institute is not to blame for delays p413

Friedrich G. Barth

doi: 10.1038/435413c

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Commentaries

Controlling avian flu at the source p415

Global agricultural authorities should harmonize with the public-health sector to ensure the exchange of flu virus samples, and establish a single international standard for vaccines, say Robert Webster and Diane Hulse.

doi: 10.1038/435415a

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A weapon the world needs p417

Both bottom-up and top-down planning is needed to prevent a global economic disaster. Michael T. Osterholm calls for action at all levels.

doi: 10.1038/435417a

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Global task force for influenza p419

Early detection and rapid response to bird flu, on a global scale, will drastically cut the costs of dealing with a full-blown human flu pandemic, argue Ron Fouchier, Thijs Kuiken, Guus Rimmelzwaan and Albert Osterhaus.

doi: 10.1038/435419a

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Is China prepared for microbial threats? p421

There is no bigger acute microbial threat to China, and to the rest of the world, than an influenza pandemic, and no better time to prepare for this eventuality than now. David Ho asks what more China could be doing.

doi: 10.1038/435421a

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Race against time p423

A committed, transparent research effort into the detection, prevention and treatment of bird flu is now critical. Anthony S. Fauci presents the questions that need answers.

doi: 10.1038/435423a

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Books and Arts

A change of mind? p425

Putting evolutionary psychology to the test.

Oliver Curry reviews Adapting Minds: Evolutionary Psychology and the Persistent Quest for Human Nature by David J. Buller

doi: 10.1038/435425a

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Exhibition:  Engineering space-time p426

Alison Abbott reviews

doi: 10.1038/435426a

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Einstein Books:  More on Einstein p427

doi: 10.1038/435427a

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A braver, newer world p427

Justine Burley reviews Never Let Me Go by Kazuo Ishiguro

doi: 10.1038/435427b

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Beating heart disease p428

Peter Sleight reviews A Change of Heart: How the People of Framingham, Massachusetts, Helped Unravel the Mysteries of Cardiovascular Disease by Daniel Levy and Susan Brink

doi: 10.1038/435428a

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Essay

The great chain of being p429

Our persistence in placing ourselves at the top of the Great Chain of Being suggests we have some deep psychological need to see ourselves as the culmination of creation.

Sean Nee

doi: 10.1038/435429a

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News and Views

Epidemiology:  Dangers of moving cows p431

The movement of cattle around the country, and the presence of badgers, are both implicated in the high incidence of bovine tuberculosis in Britain. The problem may get even worse in the near future.

Mark E. J. Woolhouse

doi: 10.1038/435431a

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Planetary science:  When giants roamed p432

An early epoch of planetary migration could explain the current orbits of the giant planets, the origin of Jupiter's Trojans, and an intense bombardment of the early Solar System with a shower of asteroids and comets.

Joe Hahn

doi: 10.1038/435432a

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Developmental biology:  A blank canvas no more p433

Embryonic cells learn their fate early in development. Discovery of a factor that controls the development of one embryonic tissue, the ectoderm, highlights a mechanism that might also influence the growth of cancer cells.

Yoshiki Sasai

doi: 10.1038/435433a

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Ultrafast science:  Molecular structure in an instant p435

The observation that there is interference between a laser-induced electron wave and a single molecule means that it may be possible to image changes in molecular structure with a sub-femtosecond resolution.

Jonathan P. Marangos

doi: 10.1038/435435a

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100 and 50 years ago p436

doi: 10.1038/435436a

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Plant biology:  Auxin action p436

Farmers and gardeners have long taken advantage of the growth-altering properties of the plant hormone auxin. The discovery of the elusive auxin receptor hints at how plant cells 'sense' and respond to this protein.

Judy Callis

doi: 10.1038/435436b

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Particle physics:  Electrons are not ambidextrous p437

The best low-energy measurement yet obtained of the electroweak mixing angle — a central parameter of the standard model of particle physics — is the last hurrah for Stanford's powerful two-mile linear accelerator.

Andrzej Czarnecki and William J. Marciano

doi: 10.1038/435437a

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Brief Communications

Cognitive psychology:  Rare items often missed in visual searches p439

Errors in spotting key targets soar alarmingly if they appear only infrequently during screening.

Jeremy M. Wolfe, Todd S. Horowitz and Naomi M. Kenner

doi: 10.1038/435439a

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Bose−Einstein condensates:  Microscopic magnetic-field imaging p440

Stephan Wildermuth, Sebastian Hofferberth, Igor Lesanovsky, Elmar Haller, L. Mauritz Andersson, Sönke Groth, Israel Bar-Joseph, Peter Krüger and Jörg Schmiedmayer

doi: 10.1038/435440a

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Brief Communications Arising

Water Behaviour: Glass transition in hyperquenched water? pE1

Ingrid Kohl, Luis Bachmann, Erwin Mayer, Andreas Hallbrucker and Thomas Loerting

doi: 10.1038/nature03707

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Water behaviour: Glass transition in hyperquenched water? (reply) pE1

Yuanzheng Yue and C. Austen Angell

doi: 10.1038/nature03708

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Articles

The F-box protein TIR1 is an auxin receptor p441

Nihal Dharmasiri, Sunethra Dharmasiri and Mark Estelle

doi: 10.1038/nature03543

Abstract | Full Text | PDF (499K)

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The Arabidopsis F-box protein TIR1 is an auxin receptor p446

Stefan Kepinski and Ottoline Leyser

doi: 10.1038/nature03542

Abstract | Full Text | PDF (279K)

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A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity p452

Carola G. Vinuesa, Matthew C. Cook, Constanza Angelucci, Vicki Athanasopoulos, Lixin Rui, Kim M. Hill, Di Yu, Heather Domaschenz, Belinda Whittle, Teresa Lambe, Ian S. Roberts, Richard R. Copley, John I. Bell, Richard J. Cornall and Christopher C. Goodnow

doi: 10.1038/nature03555

Abstract | Full Text | PDF (692K) | Supplementary information

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Letters

Origin of the orbital architecture of the giant planets of the Solar System p459

K. Tsiganis, R. Gomes, A. Morbidelli and H. F. Levison

doi: 10.1038/nature03539

First paragraph | Full Text | PDF (329K) | Supplementary information

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Chaotic capture of Jupiter's Trojan asteroids in the early Solar System p462

A. Morbidelli, H. F. Levison, K. Tsiganis and R. Gomes

doi: 10.1038/nature03540

First paragraph | Full Text | PDF (187K)

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Origin of the cataclysmic Late Heavy Bombardment period of the terrestrial planets p466

R. Gomes, H. F. Levison, K. Tsiganis and A. Morbidelli

doi: 10.1038/nature03676

First paragraph | Full Text | PDF (1,388K)

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Quantum interference during high-order harmonic generation from aligned molecules p470

Tsuneto Kanai, Shinichirou Minemoto and Hirofumi Sakai

doi: 10.1038/nature03577

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Enhanced current transport at grain boundaries in high-T_c superconductors p475

R. F. Klie, J. P. Buban, M. Varela, A. Franceschetti, C. Jooss, Y. Zhu, N. D. Browning, S. T. Pantelides and S. J. Pennycook

doi: 10.1038/nature03644

First paragraph | Full Text | PDF (220K) | Supplementary information

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Changes in carbon dioxide during an oceanic anoxic event linked to intrusion into Gondwana coals p479

Jennifer C. McElwain, Jessica Wade-Murphy and Stephen P. Hesselbo

doi: 10.1038/nature03618

First paragraph | Full Text | PDF (318K) | Supplementary information

Seismological evidence for mosaic structure of the surface of the Earth's inner core p483

Dmitry N. Krasnoshchekov, Peter B. Kaazik and Vladimir M. Ovtchinnikov

doi: 10.1038/nature03613

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Tree use by koalas in a chemically complex landscape p488

Ben D. Moore and William J. Foley

doi: 10.1038/nature03551

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Cattle movements and bovine tuberculosis in Great Britain p491

M. Gilbert, A. Mitchell, D. Bourn, J. Mawdsley, R. Clifton-Hadley and W. Wint

doi: 10.1038/nature03548

First paragraph | Full Text | PDF (364K) | Supplementary information

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Allosteric modulation of the presynaptic Ca²⁺ sensor for vesicle fusion p497

Xuelin Lou, Volker Scheuss and Ralf Schneggenburger

doi: 10.1038/nature03568

First paragraph | Full Text | PDF (552K) | Supplementary information

Vascular respiratory uncoupling increases blood pressure and atherosclerosis p502

Carlos Bernal-Mizrachi, Allison C. Gates, Sherry Weng, Takuji Imamura, Russell H. Knutsen, Pascual DeSantis, Trey Coleman, R. Reid Townsend, Louis J. Muglia and Clay F. Semenkovich

doi: 10.1038/nature03527

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Polo kinase links the stress pathway to cell cycle control and tip growth in fission yeast p507

Janni Petersen and Iain M. Hagan

doi: 10.1038/nature03590

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Structural and mechanistic insights into the interaction between Rho and mammalian Dia p513

R. Rose, M. Weyand, M. Lammers, T. Ishizaki, M. R. Ahmadian and A. Wittinghofer

doi: 10.1038/nature03604

First paragraph | Full Text | PDF (459K) | Supplementary information

Structural basis for the regulation of tubulin by vinblastine p519

Benoît Gigant, Chunguang Wang, Raimond B. G. Ravelli, Fanny Roussi, Michel O. Steinmetz, Patrick A. Curmi, André Sobel and Marcel Knossow

doi: 10.1038/nature03566

First paragraph | Full Text | PDF (294K) | Supplementary information

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Insights into microtubule nucleation from the crystal structure of human -tubulin p523

Hector Aldaz, Luke M. Rice, Tim Stearns and David A. Agard

doi: 10.1038/nature03586

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Erratum: Foreshock sequences and short-term earthquake predictability on East Pacific Rise transform faults p528

Jeffrey J. McGuire, Margaret S. Boettcher and Thomas H. Jordan

doi: 10.1038/nature03621

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Corrigendum: Low dose oral cannabinoid therapy reduces progression of atherosclerosis in mice p528

Sabine Steffens, Niels R. Veillard, Claire Arnaud, Graziano Pelli, Fabienne Burger, Christian Staub, Meliha Karsak, Andreas Zimmer, Jean-Louis Frossard and François Mach

doi: 10.1038/nature03655

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Corrigendum: A universal trend of amino acid gain and loss in protein evolution p528

I. King Jordan, Fyodor A. Kondrashov, Ivan A. Adzhubei, Yuri I. Wolf, Eugene V. Koonin, Alexey S. Kondrashov and Shamil Sunyaev

doi: 10.1038/nature03656

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Erratum: Reduction of hysteresis losses in the magnetic refrigerant Gd₅Ge₂Si₂ by the addition of iron p528

Virgil Provenzano, Alexander J. Shapiro and Robert D. Shull

doi: 10.1038/nature03683

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Erratum: Ecological constraints on diversification in a model adaptive radiation p528

Rees Kassen, Martin Llewellyn and Paul B. Rainey

doi: 10.1038/nature03684

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Naturejobs

Attractive information p529

Some suggestions to promote international scientists in the United States could be more broadly applied.

Paul Smaglik

doi:10.1038/nj7041-529a

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Gene therapy rising? p530

Once hyped, gene therapy still holds promise as an effective method for treating a variety of diseases. On the road to fulfilling that expectation, opportunities exist for young scientists who are excited by a still-emerging field, says Hannah Hoag.

Hannah Hoag

doi:10.1038/nj7041-530a

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Small is beautiful p532

Switzerland is proving that small countries can make a big impression in science. It is recruiting some of the brightest young researchers from all over the world and convincing them to stay, says Quirin Schiermeier.

Quirin Schiermeier

doi:10.1038/nj7041-532a

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Movers p534

Bioinformatician bridges maths and life sciences

Steven Salzberg

doi:10.1038/nj7041-534a

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Recruiters & Academia p534

Academics worry about hiring "undiscovered geniuses"

Wendy M. Williams & Stephen J. Ceci

doi:10.1038/nj7041-534b

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Graduate Journal:  Breaking the ice p534

Student beats nerves to turn a poster into a presentation

Karolina Tkaczuk

doi:10.1038/nj7041-534c

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Spotlight on Switzerland

doi:10.1038/nj0071

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Futures

New hope for the dead p536

Don't take this lying down!

David Langford

doi: 10.1038/435536a

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