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Nature , 118-122 (5 May 2005) | doi:10.1038/nature03508;

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A synthetic gene|[ndash]|metabolic oscillator

Autonomous oscillations found in gene expression and metabolic, cardiac and neuronal systems have attracted significant attention both because of their obvious biological roles and their intriguing dynamics. In addition, de novo designed oscillators have been demonstrated, using components that are not part of the natural oscillators.

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