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Nature 435, 37-38 (5 May 2005) | doi:10.1038/435037a; Published online 4 May 2005
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BE / BC Gastroenterologist
- Meadville Medical Center
- Meadville, PA
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- Max-Planck-Institute (MPI) of Immunobiology
- Freiburg Germany
Cell biology: Sterol sensor comes up for air
Renee M. Garza1 & Randolph Y. Hampton1
Abstract
In one example of a feedback mechanism in mammals, cells switch cholesterol synthesis on or off depending on the availability of sterol. A rewired version of this pathway in yeast acts instead as an oxygen sensor.
Writing in Cell, Espenshade and colleagues1 describe a previously unknown strategy by which cells sense oxygen levels. The mechanism uses an evolutionarily conserved and medically relevant pathway for sterol regulation in an unexpected way.
- Renee M. Garza and Randolph Y. Hampton are in the Section of Cell and Developmental Biology, Division of Biological Sciences, University of California at San Diego, La Jolla, California 92093-0347, USA.
e-mail: Email: rhampton@ucsd.edu
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