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Correspondence
Nature 434, 1067 (28 April 2005) | doi:10.1038/4341067a; Published online 27 April 2005
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Organic Chemistry
- Praj Matrix - Praj Industries Ltd
- Pune, Maharashtra Pune-411021 India
Gastrointestinal Pathologist
- Brigham and Women's Hospital
- Boston, MA
A drug is effective if better than a harmless control
Brooks Jackson1 & Thomas Fleming2
- Johns Hopkins School of Medicine, 600 North Wolfe Street, Baltimore, Maryland 21287, USA
- Department of Biostatistics, University of Washington, Box 357232, Seattle, Washington 98195, USA
Abstract
Valid trials can still be held, as with HIVNET 012, when ethics rules out a placebo group.
In his Correspondence letter "HIV drug remains unproven without placebo trial" (Nature 434, 137; 2005), Valendar Turner asks on what basis it can be claimed that the single-dose nevirapine regimen is effective in reducing mother-to-infant HIV transmission.He points out that the placebo arm was dropped in the HIVNET 012 trial (of which we were team members) and notes the high variability in reported historical HIV transmission rates.
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