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Nature 434, 965-966 (21 April 2005) | doi:10.1038/434965a; Published online 20 April 2005
Metabolism: A higher power for insulin
Fiona M. Gribble1
Abstract
Glucose output from the liver is tightly regulated by insulin. But insulin holds sway over more than the liver — an unappreciated circuit in glucose control involves the opening of ion channels in the brain.
Developed countries are currently witnessing a surge in the incidence of adult-onset (type 2) diabetes, driven by soaring levels of obesity. Insulin, the hormone that normally coordinates the disposal of glucose after a meal, becomes less effective in obesity, resulting in the high blood-glucose concentration that is the hallmark of diabetes.
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