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From the following article:

Spatiotemporal regulation of MyD88–IRF-7 signalling for robust type-I interferon induction

Kenya Honda, Yusuke Ohba, Hideyuki Yanai, Hideo Negishi, Tatsuaki Mizutani, Akinori Takaoka, Choji Taya & Tadatsugu Taniguchi

Nature 434, 1035-1040(21 April 2005)

doi:10.1038/nature03547

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Figure 1 - Unfortunately we are unable to provide accessible alternative text for this. If you require assistance to access this image, or to obtain a text description, please contact npg@nature.com

Figure 1

Trafficking of CpG ODNs in DCs.

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Figure 2

Subcellular localization of MyD88 and IRF-7, and trafficking of CpG ODNs in a macrophage cell line.

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Figure 3

High production of type-I IFN in BM-derived cDCs achieved by manipulating CpG-A trafficking with DOTAP.

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Figure 4

Induction of type-I IFN by manipulating ODN trafficking using DOTAP.

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