Supplementary information
From the following article:
A common sex-dependent mutation in a RET enhancer underlies Hirschsprung disease risk
Eileen Sproat Emison, Andrew S. McCallion, Carl S. Kashuk, Richard T. Bush, Elizabeth Grice, Shin Lin, Matthew E. Portnoy, David J. Cutler, Eric D. Green and Aravinda Chakravarti
Nature 434, 857-863(14 April 2005)
doi:10.1038/nature03467
Supplementary Table S1
Positions of all identified MCSs. Nucleotide positions are given on human chromosome 10 relative to build 34 (July 2003) of the genome.
Supplementary Table S2
Predicted transcription factor binding sites in MCS+9.7. TRANSFAC predictions of putative transcription factor binding sites given with reference to build 34 of the human genome.
Supplementary Table S3
Haplotype frequencies in Africa, Asia, Europe and HSCR cases. PHASE was used to reconstruct haplotypes in the 5' region of RET.
Supplementary Figure S1
Multi-species alignment showing the position of RET+3 within the context of MCS+9.7.
Supplementary Methods
Additional methodological details are provided in this file.
DOWNLOAD BROWSER PLUGINS AND OTHER APPLICATIONS
Movie files
PDF douments
Text documents
PostScript documents
Flash movies
Audio files
- Apple iTunes (PC or Mac)
- QuickTime Player (PC or Mac)
- Realplayer (PC or Mac)
- Windows Media player (PC only)
