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From the following article:

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

Hannah Farmer, Nuala McCabe, Christopher J. Lord, Andrew N. J. Tutt, Damian A. Johnson, Tobias B. Richardson, Manuela Santarosa, Krystyna J. Dillon, Ian Hickson, Charlotte Knights, Niall M. B. Martin, Stephen P. Jackson, Graeme C. M. Smith and Alan Ashworth

Nature 434, 917-921(14 April 2005)

doi:10.1038/nature03445

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Figure 1 - Unfortunately we are unable to provide accessible alternative text for this. If you require assistance to access this image, or to obtain a text description, please contact npg@nature.com

Figure 1

Depletion or inhibition of PARP1 selectively reduces the viability of BRCA1- and BRCA2-deficient ES cells.

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Figure 2

DSB formation and repair after exposure to PARP inhibitor.

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Figure 3

PARP inhibition selectively blocks the growth of BRCA2-deficient tumours in vivo.

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Figure 4

A model for the selective effects of PARP inhibition on cells lacking wild-type BRCA1 and BRCA2.

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