Sodium channel mutation leading to saxitoxin resistance in clams increases risk of PSP

doi:doi:10.1038/nature03415

From the following article:

Sodium channel mutation leading to saxitoxin resistance in clams increases risk of PSP

V. Monica Bricelj, Laurie Connell, Keiichi Konoki, Scott P. MacQuarrie, Todd Scheuer, William A. Catterall and Vera L. Trainer

Nature 434, 763-767(7 April 2005)

doi:10.1038/nature03415

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Supplementary Figure S1

Illustrates voltage-dependent electrophysiological properties (activation and inactivation of the Na+ current) of transfected wild-type and mutant Na⁺ channels.

Supplementary Figure S1 - Download Word file (567KB)

Supplementary Discussion

Includes a discussion of differences in the sensitivity to toxins between Mya arenaria nerves and transfected Na⁺ channels, and references cited therein.

Supplementary Discussion - Download Word file (27KB)

Supplementary Methods

Describes the methods of clam nucleic acid extraction, production of cDNA, isolation of Na⁺ channel specific fragments, determination of the Na⁺ channel sequence from individual clams, and the construction of Na⁺ channel mutations, including cited references.

Supplementary Methods - Download Word file (41KB)

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