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Editorial

Uncomfortable truths p681

A thorough investigation of German scientists' actions under the Nazi regime reveals a more complex and ambiguous story than that implanted in the public mind at the end of the Second World War.

doi:10.1038/434681a


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News

Warning system steps up a gear for fresh Indonesian earthquake p683

Alerts about risk of tsunami spread quickly.

Declan Butler

doi:10.1038/434683a


Pope praised for partial conciliation of science and religion p684

Scientists pay their respects to John Paul II.

Quirin Schiermeier

doi:10.1038/434684a


Nuclear chiefs scotch story on frailty of ageing warheads p684

Thirty-year-old nuclear bombs do not have a design flaw, say scientists.

Geoff Brumfiel

doi:10.1038/434684b


Job switch stymies Japan's abduction probe p685

Geneticist's new post could stop him testifying about DNA tests.

David Cyranoski

doi:10.1038/434685a


Image problems jeopardize comet mission's impact p685

NASA engineers struggle to focus their comet camera.

Rex Dalton

doi:10.1038/434685b


Global health agency split over potential anti-terrorism duties p686

Bioterror role could compromise World Health Organization, critics say.

Erika Check

doi:10.1038/434686a


Professors bristle as states act to mould lecture content p686

Academics are fighting right-wing 'bills of rights'.

Emma Marris

doi:10.1038/434686b


US abandons health study on Agent Orange p687

Cultural divide condemns Vietnam project.

Declan Butler

doi:10.1038/434687a


Postdocs slam zealous attitude of NIH ethics office p687

Ethical rules now defy common sense, researchers say.

Rex Dalton

doi:10.1038/434687b


news in brief p688

doi:10.1038/434688a


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News Features

Tropical medicine:  Melioidosis? Never heard of it... p692

Deadly tropical infections that kill within 48 hours don't usually go unnoticed. But one killer has been largely ignored for decades. Now, thanks to worries about bioterror, it is being taken more seriously. Peter Aldhous reports.

doi:10.1038/434692a


Stem-cell research:  After the gold rush p694

California's voters have authorized the spending of $3 billion over the next decade on stem-cell research. But will this bonanza bring threats as well as opportunities? Peter Aldhous weighs the hopes and fears.

doi:10.1038/434694a


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Correspondence

Arrogance imperils plans for change at Harvard p697

An abrasive president may find it counterproductive to alienate so much of the faculty.

Ben A. Barres

doi:10.1038/434697a


DNA barcoding is no substitute for taxonomy p697

Malte C. Ebach and Craig Holdrege

doi:10.1038/434697b


Don't mix radiocarbon and calendar years p697

Chris Tyler-Smith, Matthew E. Hurles and Mark A. Jobling

doi:10.1038/434697c


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Commentary

A global call for new polio vaccines p699

The end is near but eradication will not be as simple as once thought.

doi:10.1038/434699a

See also: Editor's summary


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Books and Arts

Emerging physics p701

A fresh approach to viewing the complexity of the Universe.

Philip Anderson reviews A Different Universe: Reinventing Physics from the Bottom Down by Robert Laughlin

doi:10.1038/434701a


Don't talk to the animals p702

Neil Smith reviews Doctor Dolittle's Delusion: Animals and the Uniqueness of Human Language by Stephen R. Anderson

doi:10.1038/434702a


Exhibition:  Hirst's hobbit p702

Michael Hopkin

doi:10.1038/434702b


Aventis Science Book Prize shortlist announced p703

doi:10.1038/434703a


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Essay

Concept

Stirring the primordial soup p705

RNA world: does changing the direction of replication make RNA life viable?

William R. Taylor

doi:10.1038/434705a


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News and Views

Planetary science : A planet that blinks p707

Infrared radiation from two extrasolar planets has been measured from the dip in total light as the planets pass behind their parent stars — a milestone on the road to the direct imaging of such planets.

Karl Stapelfeldt

doi:10.1038/434707a

See also: Editor's summary


Pharmacology:  Marijuana and your heart p708

Marijuana smoke can have harmful effects on the heart. But one of its active components may ease inflammation and slow the progression of coronary artery disease.

Michael D. Roth

doi:10.1038/434708a

See also: Editor's summary


Tuberculosis:  The genetics of vulnerability p709

Susceptibility to tuberculosis is known to be under complex genetic control in humans, but what are the genes involved? A mouse strain that is unusually prone to the disease shows the way.

Nada Jabado and Philippe Gros

doi:10.1038/434709a

See also: Editor's summary


100 and 50 years ago p711

doi:10.1038/434711a


Technology:  Hydrogen and hydrates p712

It's a potentially explosive issue. How can hydrogen be stored cleanly, efficiently and, above all, safely? One answer would appear to be: take a cage made of water, and add just a little organic solvent.

Ferdi Schüth

doi:10.1038/434712a

See also: Editor's summary


Environmental science:  Germ theory for ailing corals p713

Human activities damage coral reef ecosystems. Application of the 'germ theory', proposed more than a century ago for human diseases, could foster action on global environmental ailments such as this.

Stephen R. Palumbi

doi:10.1038/434713a


Developmental biology:  Reproduction in clusters p715

Homeobox genes have some quirky features: they huddle together and tend to be expressed in the order that they appear in their cluster. A new cluster, specific to reproductive development, has now been discovered.

François Spitz and Denis Duboule

doi:10.1038/434715a


Evolutionary biology:  Channels of resistance p716

Rory Howlett

doi:10.1038/434716a


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Brief Communications

History of science:  Dante's insight into galilean invariance p717

The poet's vividly imagined flight unwittingly captures a physical law of motion.

Leonardo Ricci

doi:10.1038/434717a

See also: Editor's summary


Anthropology:  The earliest toothless hominin skull p717

David Lordkipanidze, Abesalom Vekua, Reid Ferring, G. Philip Rightmire, Jordi Agusti, Gocha Kiladze, Alexander Mouskhelishvili, Medea Nioradze, Marcia S. Ponce de León, Martha Tappen and Christoph P. E. Zollikofer

doi:10.1038/434717b


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Articles

Modes of faulting at mid-ocean ridges p719

W. Roger Buck, Luc L. Lavier and Alexei N. B. Poliakov

doi:10.1038/nature03358


Generation and annotation of the DNA sequences of human chromosomes 2 and 4 p724

LaDeana W. Hillier, Tina A. Graves, Robert S. Fulton, Lucinda A. Fulton, Kymberlie H. Pepin, Patrick Minx, Caryn Wagner-McPherson, Dan Layman, Kristine Wylie, Mandeep Sekhon, Michael C. Becker, Ginger A. Fewell, Kimberly D. Delehaunty, Tracie L. Miner, William E. Nash, Colin Kremitzki, Lachlan Oddy, Hui Du, Hui Sun, Holland Bradshaw-Cordum, Johar Ali, Jason Carter, Matt Cordes, Anthony Harris, Amber Isak, Andrew van Brunt, Christine Nguyen, Feiyu Du, Laura Courtney, Joelle Kalicki, Philip Ozersky, Scott Abbott, Jon Armstrong, Edward A. Belter, Lauren Caruso, Maria Cedroni, Marc Cotton, Teresa Davidson, Anu Desai, Glendoria Elliott, Thomas Erb, Catrina Fronick, Tony Gaige, William Haakenson, Krista Haglund, Andrea Holmes, Richard Harkins, Kyung Kim, Scott S. Kruchowski, Cynthia Madsen Strong, Neenu Grewal, Ernest Goyea, Shunfang Hou, Andrew Levy, Scott Martinka, Kelly Mead, Michael D. McLellan, Rick Meyer, Jennifer Randall-Maher, Chad Tomlinson, Sara Dauphin-Kohlberg, Amy Kozlowicz-Reilly, Neha Shah, Sharhonda Swearengen-Shahid, Jacqueline Snider, Joseph T. Strong, Johanna Thompson, Martin Yoakum, Shawn Leonard, Charlene Pearman, Lee Trani, Maxim Radionenko, Jason E. Waligorski, Chunyan Wang, Susan M. Rock, Aye-Mon Tin-Wollam, Rachel Maupin, Phil Latreille, Michael C. Wendl, Shiaw-Pyng Yang, Craig Pohl, John W. Wallis, John Spieth, Tamberlyn A. Bieri, Nicolas Berkowicz, Joanne O. Nelson, John Osborne, Li Ding, Rekha Meyer, Aniko Sabo, Yoram Shotland, Prashant Sinha, Patricia E. Wohldmann, Lisa L. Cook, Matthew T. Hickenbotham, James Eldred, Donald Williams, Thomas A. Jones, Xinwei She, Francesca D. Ciccarelli, Elisa Izaurralde, James Taylor, Jeremy Schmutz, Richard M. Myers, David R. Cox, Xiaoqiu Huang, John D. McPherson, Elaine R. Mardis, Sandra W. Clifton, Wesley C. Warren, Asif T. Chinwalla, Sean R. Eddy, Marco A. Marra, Ivan Ovcharenko, Terrence S. Furey, Webb Miller, Evan E. Eichler, Peer Bork, Mikita Suyama, David Torrents, Robert H. Waterston and Richard K. Wilson

doi:10.1038/nature03466

See also: Editor's summary


Recruitment of entomopathogenic nematodes by insect-damaged maize roots p732

Sergio Rasmann, Tobias G. Köllner, Jörg Degenhardt, Ivan Hiltpold, Stefan Toepfer, Ulrich Kuhlmann, Jonathan Gershenzon and Ted C. J. Turlings

doi:10.1038/nature03451

See also: Editor's summary


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Letters to Nature

Rapid growth of black holes in massive star-forming galaxies p738

D. M. Alexander, I. Smail, F. E. Bauer, S. C. Chapman, A. W. Blain, W. N. Brandt and R. J. Ivison

doi:10.1038/nature03473

See also: Editor's summary


Infrared radiation from an extrasolar planet p740

Drake Deming, Sara Seager, L. Jeremy Richardson and Joseph Harrington

doi:10.1038/nature03507

See also: Editor's summary | News and Views by Stapelfeldt


Tuning clathrate hydrates for hydrogen storage p743

Huen Lee, Jong-won Lee, Do Youn Kim, Jeasung Park, Yu-Taek Seo, Huang Zeng, Igor L. Moudrakovski, Christopher I. Ratcliffe and John A. Ripmeester

doi:10.1038/nature03457

See also: Editor's summary | News and Views by Schüth


Water content in the transition zone from electrical conductivity of wadsleyite and ringwoodite p746

Xiaoge Huang, Yousheng Xu and Shun-ichiro Karato

doi:10.1038/nature03426


Particle size and energetics of gouge from earthquake rupture zones p749

Brent Wilson, Thomas Dewers, Ze'ev Reches and James Brune

doi:10.1038/nature03433

See also: Editor's summary


New material of the earliest hominid from the Upper Miocene of Chad p752

Michel Brunet, Franck Guy, David Pilbeam, Daniel E. Lieberman, Andossa Likius, Hassane T. Mackaye, Marcia S. Ponce de León, Christoph P. E. Zollikofer and Patrick Vignaud

doi:10.1038/nature03392

See also: Editor's summary


Virtual cranial reconstruction of Sahelanthropus tchadensis p755

Christoph P. E. Zollikofer, Marcia S. Ponce de León, Daniel E. Lieberman, Franck Guy, David Pilbeam, Andossa Likius, Hassane T. Mackaye, Patrick Vignaud and Michel Brunet

doi:10.1038/nature03397

See also: Editor's summary


Evolutionary diversification of TTX-resistant sodium channels in a predator–prey interaction p759

Shana L. Geffeney, Esther Fujimoto, Edmund D. Brodie, III, Edmund D. Brodie, Jr and Peter C. Ruben

doi:10.1038/nature03444


Sodium channel mutation leading to saxitoxin resistance in clams increases risk of PSP p763

V. Monica Bricelj, Laurie Connell, Keiichi Konoki, Scott P. MacQuarrie, Todd Scheuer, William A. Catterall and Vera L. Trainer

doi:10.1038/nature03415


Ipr1 gene mediates innate immunity to tuberculosis p767

Hui Pan, Bo-Shiun Yan, Mauricio Rojas, Yuriy V. Shebzukhov, Hongwei Zhou, Lester Kobzik, Darren E. Higgins, Mark J. Daly, Barry R. Bloom and Igor Kramnik

doi:10.1038/nature03419

See also: Editor's summary | News and Views by Jabado & Gros


IRF-7 is the master regulator of type-I interferon-dependent immune responses p772

Kenya Honda, Hideyuki Yanai, Hideo Negishi, Masataka Asagiri, Mitsuharu Sato, Tatsuaki Mizutani, Naoya Shimada, Yusuke Ohba, Akinori Takaoka, Nobuaki Yoshida and Tadatsugu Taniguchi

doi:10.1038/nature03464


Self-organized patchiness in asthma as a prelude to catastrophic shifts p777

Jose G. Venegas, Tilo Winkler, Guido Musch, Marcos F. Vidal Melo, Dominick Layfield, Nora Tgavalekos, Alan J. Fischman, Ronald J. Callahan, Giacomo Bellani and R. Scott Harris

doi:10.1038/nature03490

See also: Editor's summary


Low dose oral cannabinoid therapy reduces progression of atherosclerosis in mice p782

Sabine Steffens, Niels R. Veillard, Claire Arnaud, Graziano Pelli, Fabienne Burger, Christian Staub, Andreas Zimmer, Jean-Louis Frossard and François Mach

doi:10.1038/nature03389

See also: Editor's summary | News and Views by Roth


Impairment of angiogenesis and cell migration by targeted aquaporin-1 gene disruption p786

Samira Saadoun, Marios C. Papadopoulos, Mariko Hara-Chikuma and A. S. Verkman

doi:10.1038/nature03460


Addendum: Strong polarization enhancement in asymmetric three-component ferroelectric superlattices p792

Ho Nyung Lee, Hans M. Christen, Matthew F. Chisholm, Christopher M. Rouleau and Douglas H. Lowndes

doi:10.1038/nature03517


Erratum : Mesozoic Alpine facies deposition as a result of past latitudinal plate motion p792

Giovanni Muttoni, Elisabetta Erba, Dennis V. Kent and Valerian Bachtadse

doi:10.1038/nature03545


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Technology Features

Protein purification:  Pure but not simple p795

Protein purification is stepping into the limelight, as proteomics researchers demand faster ways to purify more proteins. Tim Chapman looks at what is around to help them.

Tim Chapman

doi:10.1038/434795a


Small-scale separation p795

doi:10.1038/434795b


Attracting attention p796

doi:10.1038/434796a


Automation in two dimensions p797

doi:10.1038/434797a


Table of suppliers p799

doi:10.1038/434799a


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Naturejobs

Prospects

Guiding hands p801

Paul Smaglik

doi:10.1038/nj7034-801a


Special report

Model mentors p802

We all know a special person who has inspired us. Paul Smaglik learns from the winners of the first UK award for excellent mentoring in science.

Paul Smaglik

doi:10.1038/nj7034-802a


Career View

Graduate Journal:  Goodbye to romance p804

Tobias Langenhan

doi:10.1038/nj7034-804a


Nuts & Bolts p804

Deb Koen

doi:10.1038/nj7034-804b


Movers p804

doi:10.1038/nj7034-804c


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Futures

Ivory Tower p806

A place to call our own.

Bruce Sterling

doi:10.1038/434806a


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