Table of contents
Volume 434 Number 7034 pp681-806
Editorial
Uncomfortable truths p681
A thorough investigation of German scientists' actions under the Nazi regime reveals a more complex and ambiguous story than that implanted in the public mind at the end of the Second World War.
doi:10.1038/434681a
News
Warning system steps up a gear for fresh Indonesian earthquake p683
Alerts about risk of tsunami spread quickly.
Declan Butler
doi:10.1038/434683a
Pope praised for partial conciliation of science and religion p684
Scientists pay their respects to John Paul II.
Quirin Schiermeier
doi:10.1038/434684a
Nuclear chiefs scotch story on frailty of ageing warheads p684
Thirty-year-old nuclear bombs do not have a design flaw, say scientists.
Geoff Brumfiel
doi:10.1038/434684b
Job switch stymies Japan's abduction probe p685
Geneticist's new post could stop him testifying about DNA tests.
David Cyranoski
doi:10.1038/434685a
Image problems jeopardize comet mission's impact p685
NASA engineers struggle to focus their comet camera.
Rex Dalton
doi:10.1038/434685b
Global health agency split over potential anti-terrorism duties p686
Bioterror role could compromise World Health Organization, critics say.
Erika Check
doi:10.1038/434686a
Professors bristle as states act to mould lecture content p686
Academics are fighting right-wing 'bills of rights'.
Emma Marris
doi:10.1038/434686b
US abandons health study on Agent Orange p687
Cultural divide condemns Vietnam project.
Declan Butler
doi:10.1038/434687a
Postdocs slam zealous attitude of NIH ethics office p687
Ethical rules now defy common sense, researchers say.
Rex Dalton
doi:10.1038/434687b
News Features
Tropical medicine: Melioidosis? Never heard of it... p692
Deadly tropical infections that kill within 48 hours don't usually go unnoticed. But one killer has been largely ignored for decades. Now, thanks to worries about bioterror, it is being taken more seriously. Peter Aldhous reports.
doi:10.1038/434692a
Stem-cell research: After the gold rush p694
California's voters have authorized the spending of $3 billion over the next decade on stem-cell research. But will this bonanza bring threats as well as opportunities? Peter Aldhous weighs the hopes and fears.
doi:10.1038/434694a
Correspondence
Arrogance imperils plans for change at Harvard p697
An abrasive president may find it counterproductive to alienate so much of the faculty.
Ben A. Barres
doi:10.1038/434697a
DNA barcoding is no substitute for taxonomy p697
Malte C. Ebach and Craig Holdrege
doi:10.1038/434697b
Don't mix radiocarbon and calendar years p697
Chris Tyler-Smith, Matthew E. Hurles and Mark A. Jobling
doi:10.1038/434697c
Commentary
A global call for new polio vaccines p699
The end is near but eradication will not be as simple as once thought.
doi:10.1038/434699a
See also: Editor's summary
Books and Arts
Emerging physics p701
A fresh approach to viewing the complexity of the Universe.
Philip Anderson reviews A Different Universe: Reinventing Physics from the Bottom Down by Robert Laughlin
doi:10.1038/434701a
Don't talk to the animals p702
Neil Smith reviews Doctor Dolittle's Delusion: Animals and the Uniqueness of Human Language by Stephen R. Anderson
doi:10.1038/434702a
Exhibition: Hirst's hobbit p702
Michael Hopkin
doi:10.1038/434702b
Aventis Science Book Prize shortlist announced p703
doi:10.1038/434703a
Essay
ConceptStirring the primordial soup p705
RNA world: does changing the direction of replication make RNA life viable?
William R. Taylor
doi:10.1038/434705a
News and Views
Planetary science : A planet that blinks p707
Infrared radiation from two extrasolar planets has been measured from the dip in total light as the planets pass behind their parent stars — a milestone on the road to the direct imaging of such planets.
Karl Stapelfeldt
doi:10.1038/434707a
See also: Editor's summary
Pharmacology: Marijuana and your heart p708
Marijuana smoke can have harmful effects on the heart. But one of its active components may ease inflammation and slow the progression of coronary artery disease.
Michael D. Roth
doi:10.1038/434708a
See also: Editor's summary
Tuberculosis: The genetics of vulnerability p709
Susceptibility to tuberculosis is known to be under complex genetic control in humans, but what are the genes involved? A mouse strain that is unusually prone to the disease shows the way.
Nada Jabado and Philippe Gros
doi:10.1038/434709a
See also: Editor's summary
100 and 50 years ago p711
doi:10.1038/434711a
Technology: Hydrogen and hydrates p712
It's a potentially explosive issue. How can hydrogen be stored cleanly, efficiently and, above all, safely? One answer would appear to be: take a cage made of water, and add just a little organic solvent.
Ferdi Schüth
doi:10.1038/434712a
See also: Editor's summary
Environmental science: Germ theory for ailing corals p713
Human activities damage coral reef ecosystems. Application of the 'germ theory', proposed more than a century ago for human diseases, could foster action on global environmental ailments such as this.
Stephen R. Palumbi
doi:10.1038/434713a
Developmental biology: Reproduction in clusters p715
Homeobox genes have some quirky features: they huddle together and tend to be expressed in the order that they appear in their cluster. A new cluster, specific to reproductive development, has now been discovered.
François Spitz and Denis Duboule
doi:10.1038/434715a
Evolutionary biology: Channels of resistance p716
Rory Howlett
doi:10.1038/434716a
Brief Communications
History of science: Dante's insight into galilean invariance p717
The poet's vividly imagined flight unwittingly captures a physical law of motion.
Leonardo Ricci
doi:10.1038/434717a
First paragraph | Full Text | PDF (288K)
See also: Editor's summary
Anthropology: The earliest toothless hominin skull p717
David Lordkipanidze, Abesalom Vekua, Reid Ferring, G. Philip Rightmire, Jordi Agusti, Gocha Kiladze, Alexander Mouskhelishvili, Medea Nioradze, Marcia S. Ponce de León, Martha Tappen and Christoph P. E. Zollikofer
doi:10.1038/434717b
First paragraph | Full Text | PDF (288K) | Supplementary information
Articles
Modes of faulting at mid-ocean ridges p719
W. Roger Buck, Luc L. Lavier and Alexei N. B. Poliakov
doi:10.1038/nature03358
Abstract | Full Text | PDF (290K) | Supplementary information
Generation and annotation of the DNA sequences of human chromosomes 2 and 4 p724
LaDeana W. Hillier, Tina A. Graves, Robert S. Fulton, Lucinda A. Fulton, Kymberlie H. Pepin, Patrick Minx, Caryn Wagner-McPherson, Dan Layman, Kristine Wylie, Mandeep Sekhon, Michael C. Becker, Ginger A. Fewell, Kimberly D. Delehaunty, Tracie L. Miner, William E. Nash, Colin Kremitzki, Lachlan Oddy, Hui Du, Hui Sun, Holland Bradshaw-Cordum, Johar Ali, Jason Carter, Matt Cordes, Anthony Harris, Amber Isak, Andrew van Brunt, Christine Nguyen, Feiyu Du, Laura Courtney, Joelle Kalicki, Philip Ozersky, Scott Abbott, Jon Armstrong, Edward A. Belter, Lauren Caruso, Maria Cedroni, Marc Cotton, Teresa Davidson, Anu Desai, Glendoria Elliott, Thomas Erb, Catrina Fronick, Tony Gaige, William Haakenson, Krista Haglund, Andrea Holmes, Richard Harkins, Kyung Kim, Scott S. Kruchowski, Cynthia Madsen Strong, Neenu Grewal, Ernest Goyea, Shunfang Hou, Andrew Levy, Scott Martinka, Kelly Mead, Michael D. McLellan, Rick Meyer, Jennifer Randall-Maher, Chad Tomlinson, Sara Dauphin-Kohlberg, Amy Kozlowicz-Reilly, Neha Shah, Sharhonda Swearengen-Shahid, Jacqueline Snider, Joseph T. Strong, Johanna Thompson, Martin Yoakum, Shawn Leonard, Charlene Pearman, Lee Trani, Maxim Radionenko, Jason E. Waligorski, Chunyan Wang, Susan M. Rock, Aye-Mon Tin-Wollam, Rachel Maupin, Phil Latreille, Michael C. Wendl, Shiaw-Pyng Yang, Craig Pohl, John W. Wallis, John Spieth, Tamberlyn A. Bieri, Nicolas Berkowicz, Joanne O. Nelson, John Osborne, Li Ding, Rekha Meyer, Aniko Sabo, Yoram Shotland, Prashant Sinha, Patricia E. Wohldmann, Lisa L. Cook, Matthew T. Hickenbotham, James Eldred, Donald Williams, Thomas A. Jones, Xinwei She, Francesca D. Ciccarelli, Elisa Izaurralde, James Taylor, Jeremy Schmutz, Richard M. Myers, David R. Cox, Xiaoqiu Huang, John D. McPherson, Elaine R. Mardis, Sandra W. Clifton, Wesley C. Warren, Asif T. Chinwalla, Sean R. Eddy, Marco A. Marra, Ivan Ovcharenko, Terrence S. Furey, Webb Miller, Evan E. Eichler, Peer Bork, Mikita Suyama, David Torrents, Robert H. Waterston and Richard K. Wilson
doi:10.1038/nature03466
Abstract | Full Text | PDF (431K) | Supplementary information
See also: Editor's summary
Recruitment of entomopathogenic nematodes by insect-damaged maize roots p732
Sergio Rasmann, Tobias G. Köllner, Jörg Degenhardt, Ivan Hiltpold, Stefan Toepfer, Ulrich Kuhlmann, Jonathan Gershenzon and Ted C. J. Turlings
doi:10.1038/nature03451
Abstract | Full Text | PDF (344K)
See also: Editor's summary
Letters to Nature
Rapid growth of black holes in massive star-forming galaxies p738
D. M. Alexander, I. Smail, F. E. Bauer, S. C. Chapman, A. W. Blain, W. N. Brandt and R. J. Ivison
doi:10.1038/nature03473
First paragraph | Full Text | PDF (265K)
See also: Editor's summary
Infrared radiation from an extrasolar planet p740
Drake Deming, Sara Seager, L. Jeremy Richardson and Joseph Harrington
doi:10.1038/nature03507
First paragraph | Full Text | PDF (577K) | Supplementary information
See also: Editor's summary | News and Views by Stapelfeldt
Tuning clathrate hydrates for hydrogen storage p743
Huen Lee, Jong-won Lee, Do Youn Kim, Jeasung Park, Yu-Taek Seo, Huang Zeng, Igor L. Moudrakovski, Christopher I. Ratcliffe and John A. Ripmeester
doi:10.1038/nature03457
First paragraph | Full Text | PDF (273K) | Supplementary information
See also: Editor's summary | News and Views by Schüth
Water content in the transition zone from electrical conductivity of wadsleyite and ringwoodite p746
Xiaoge Huang, Yousheng Xu and Shun-ichiro Karato
doi:10.1038/nature03426
First paragraph | Full Text | PDF (255K)
Particle size and energetics of gouge from earthquake rupture zones p749
Brent Wilson, Thomas Dewers, Ze'ev Reches and James Brune
doi:10.1038/nature03433
First paragraph | Full Text | PDF (324K)
See also: Editor's summary
New material of the earliest hominid from the Upper Miocene of Chad p752
Michel Brunet, Franck Guy, David Pilbeam, Daniel E. Lieberman, Andossa Likius, Hassane T. Mackaye, Marcia S. Ponce de León, Christoph P. E. Zollikofer and Patrick Vignaud
doi:10.1038/nature03392
First paragraph | Full Text | PDF (248K)
See also: Editor's summary
Virtual cranial reconstruction of Sahelanthropus tchadensis p755
Christoph P. E. Zollikofer, Marcia S. Ponce de León, Daniel E. Lieberman, Franck Guy, David Pilbeam, Andossa Likius, Hassane T. Mackaye, Patrick Vignaud and Michel Brunet
doi:10.1038/nature03397
First paragraph | Full Text | PDF (328K) | Supplementary information
See also: Editor's summary
Evolutionary diversification of TTX-resistant sodium channels in a predator–prey interaction p759
Shana L. Geffeney, Esther Fujimoto, Edmund D. Brodie, III, Edmund D. Brodie, Jr and Peter C. Ruben
doi:10.1038/nature03444
First paragraph | Full Text | PDF (308K) | Supplementary information
Sodium channel mutation leading to saxitoxin resistance in clams increases risk of PSP p763
V. Monica Bricelj, Laurie Connell, Keiichi Konoki, Scott P. MacQuarrie, Todd Scheuer, William A. Catterall and Vera L. Trainer
doi:10.1038/nature03415
First paragraph | Full Text | PDF (310K) | Supplementary information
Ipr1 gene mediates innate immunity to tuberculosis p767
Hui Pan, Bo-Shiun Yan, Mauricio Rojas, Yuriy V. Shebzukhov, Hongwei Zhou, Lester Kobzik, Darren E. Higgins, Mark J. Daly, Barry R. Bloom and Igor Kramnik
doi:10.1038/nature03419
First paragraph | Full Text | PDF (428K) | Supplementary information
See also: Editor's summary | News and Views by Jabado & Gros
IRF-7 is the master regulator of type-I interferon-dependent immune responses p772
Kenya Honda, Hideyuki Yanai, Hideo Negishi, Masataka Asagiri, Mitsuharu Sato, Tatsuaki Mizutani, Naoya Shimada, Yusuke Ohba, Akinori Takaoka, Nobuaki Yoshida and Tadatsugu Taniguchi
doi:10.1038/nature03464
First paragraph | Full Text | PDF (494K) | Supplementary information
Self-organized patchiness in asthma as a prelude to catastrophic shifts p777
Jose G. Venegas, Tilo Winkler, Guido Musch, Marcos F. Vidal Melo, Dominick Layfield, Nora Tgavalekos, Alan J. Fischman, Ronald J. Callahan, Giacomo Bellani and R. Scott Harris
doi:10.1038/nature03490
First paragraph | Full Text | PDF (444K) | Supplementary information
See also: Editor's summary
Low dose oral cannabinoid therapy reduces progression of atherosclerosis in mice p782
Sabine Steffens, Niels R. Veillard, Claire Arnaud, Graziano Pelli, Fabienne Burger, Christian Staub, Andreas Zimmer, Jean-Louis Frossard and François Mach
doi:10.1038/nature03389
First paragraph | Full Text | PDF (420K)
See also: Editor's summary | News and Views by Roth
Impairment of angiogenesis and cell migration by targeted aquaporin-1 gene disruption p786
Samira Saadoun, Marios C. Papadopoulos, Mariko Hara-Chikuma and A. S. Verkman
doi:10.1038/nature03460
First paragraph | Full Text | PDF (421K) | Supplementary information
Addendum: Strong polarization enhancement in asymmetric three-component ferroelectric superlattices p792
Ho Nyung Lee, Hans M. Christen, Matthew F. Chisholm, Christopher M. Rouleau and Douglas H. Lowndes
doi:10.1038/nature03517
Erratum : Mesozoic Alpine facies deposition as a result of past latitudinal plate motion p792
Giovanni Muttoni, Elisabetta Erba, Dennis V. Kent and Valerian Bachtadse
doi:10.1038/nature03545
Technology Features
Protein purification: Pure but not simple p795
Protein purification is stepping into the limelight, as proteomics researchers demand faster ways to purify more proteins. Tim Chapman looks at what is around to help them.
Tim Chapman
doi:10.1038/434795a
Small-scale separation p795
doi:10.1038/434795b
Attracting attention p796
doi:10.1038/434796a
Automation in two dimensions p797
doi:10.1038/434797a
Table of suppliers p799
doi:10.1038/434799a
Naturejobs
ProspectsGuiding hands p801
Paul Smaglik
doi:10.1038/nj7034-801a
Special report
Model mentors p802
We all know a special person who has inspired us. Paul Smaglik learns from the winners of the first UK award for excellent mentoring in science.
Paul Smaglik
doi:10.1038/nj7034-802a
Career View
Graduate Journal: Goodbye to romance p804
Tobias Langenhan
doi:10.1038/nj7034-804a
Nuts & Bolts p804
Deb Koen
doi:10.1038/nj7034-804b
Movers p804
doi:10.1038/nj7034-804c
