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Nature 434, 709-711 (7 April 2005) | doi:10.1038/434709a; Published online 6 April 2005
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Senior Lecturer / Reader
- King's College London
- London United Kingdom
Faculty Position - Center for Viral Oncology
- University of Kansas Medical Center
- Kansas City, KS
Tuberculosis: The genetics of vulnerability
Abstract
Susceptibility to tuberculosis is known to be under complex genetic control in humans, but what are the genes involved? A mouse strain that is unusually prone to the disease shows the way.
It is estimated that as much as one-third of the world's population is infected with the tubercle bacillus Mycobacterium tuberculosis. Yet only one in ten infected people actually develops active tuberculosis (TB), suggesting that innate mechanisms of immune defence (among other factors) can often contain the infection1.
- Jabado is in the Department of Pediatrics, Montreal Children's Hospital, McGill University Health Center, Montreal, H3Z 2Z3, Canada.
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Philippe Gros is in the Department of Biochemistry, McGill University, Montreal, H3G 1Y6, Canada.
e-mail: Email: philippe.gros@staff.mcgill.ca
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