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Nature 434, 708-709 (7 April 2005) | doi:10.1038/434708a; Published online 6 April 2005
Pharmacology: Marijuana and your heart
Michael D. Roth1
Abstract
Marijuana smoke can have harmful effects on the heart. But one of its active components may ease inflammation and slow the progression of coronary artery disease.
The discovery of cell-surface receptors that bind to the major active component of marijuana, 
9-tetrahydrocannabinol (THC), has led to an explosion of research into the biological properties of marijuana and cannabinoids1. THC binds with equal affinity to two different receptors — CB1 and CB2.
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RESEARCH
Low dose oral cannabinoid therapy reduces progression of atherosclerosis in miceNature Letters to Editor (07 Apr 2005)