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Nature 434, 658-662 (31 March 2005) | doi:10.1038/nature03434;
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Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death
Mitochondria play a critical role in mediating both apoptotic and necrotic cell death. The mitochondrial permeability transition (mPT) leads to mitochondrial swelling, outer membrane rupture and the release of apoptotic mediators.
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