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Nature 434, 575-577 (31 March 2005) | doi:10.1038/434575a; Published online 30 March 2005
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Cell biology: The more MAD, the merrier
Robert S. Hagan1 & Peter K. Sorger1
Abstract
Cells must pass the correct number of chromosomes to their progeny through the complex ballet of cell division. An unusual conformation-sensitive switch seems to maintain accurate chromosome segregation.
The maintenance of normal chromosome number during cell division requires the precise separation of duplicated sister chromosomes into two equal sets. Andrea Mussachio and colleagues1, writing in Current Biology, shed light on how a protein called Mad2 ensures the fidelity of this process.
- Robert S. Hagan is in the Department of Biology, and Peter K. Sorger is in the Department of Biology and Biological Engineering Division, Massachusetts Institute of Technology, 77 Massachusetts Avenue, 68-371, Cambridge, Massachusetts 02139, USA.
e-mail: Email: psorger@mit.edu
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