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Nature 434, 279-280 (17 March 2005) | doi:10.1038/434279a; Published online 16 March 2005
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Genome biology: She moves in mysterious ways
Chris Gunter1
Abstract
The human X chromosome is a study in contradictions. The detailed sequence of the X, and a survey of inactivated genes in females, help to illuminate this unique 'evolutionary space'.
The X chromosome was originally named X for 'unknown', remaining an oddity that has puzzled geneticists for centuries. It is the only chromosome to have one of the pair inactivated in one sex (females), and it is riddled with repeat elements, making it especially tough to produce a detailed gene sequence.
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Chris Gunter is a senior editor based at Nature's Washington office.
Email: c.gunter@naturedc.com
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