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Nature 434, 150 (10 March 2005) | doi:10.1038/434150a; Published online 9 March 2005
Epigenetics: Surveillance team against cancer
George Klein1
Abstract
Variations in the control of a phenomenon known as parental imprinting influence the likelihood of tumour development. These new findings may tie in with an earlier concept of 'two-phase' carcinogenesis.
Cancer is often viewed as a genetic disease — one that results when the DNA sequence of key genes is mutated, leading to the removal of protective roadblocks and/or to the unchecked proliferation of cells. In recent years, however, it has become clear that 'epigenetic' malfunctions can also contribute to cancer development.
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HTTP Status 500 -
type Exception report
message
description The server encountered an internal error () that prevented it from fulfilling this request.
exception
javax.servlet.ServletException: Servlet execution threw an exception
root cause
java.lang.OutOfMemoryError
note The full stack trace of the root cause is available in the Tomcat logs.