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Editorials

Killers on the loose p123

Across the developing world, seriously ill patients can't be sure whether they're purchasing life-saving medicines or worthless dummy pills. This scandal demands a stronger response from aid donors, governments and the drugs industry.

doi:10.1038/434123a


Bad faith at Los Alamos p123

The breakdown of an old contract threatens to leave a great national laboratory gravely weakened.

doi:10.1038/434123b


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News

NASA's funding shortfall means journey's end for Voyager probes p125

Mission to the edge of the Solar System may shut down in October to save cash.

Tony Reichhardt

doi:10.1038/434125a


Senate resignations mar academy's birthday p126

European Academy of Sciences and Arts faces unrest.

Alison Abbott

doi:10.1038/434126a


Anthropologists walk tall after unearthing hominid p126

Ethiopian fossil should shed light on mankind's first upright steps.

Rex Dalton

doi:10.1038/434126b


Career charter sets out rights of Europe's young scientists p127

PhD students get leverage to be treated properly as professionals.

Quirin Schiermeier

doi:10.1038/434127a


Gene-therapy trials to restart following cancer risk review p127

US researchers to trial gene therapy on children with SCID.

Erika Check

doi:10.1038/434127b


Climatologists seek clear view of Asia's smog p128

Project to assess climate impact of massive brown clouds.

David Cyranoski and Ichiko Fuyuno

doi:10.1038/434128a


Biosafety law brings stem-cell research to Brazil p128

Extra embryos from IVF now open for research - but not for therapeutic cloning.

Laura Nelson

doi:10.1038/434128b


Police urge speedy action to clean up home drug factories p129

Illegal methamphetamine labs could turn houses to toxic dumps.

Emma Marris

doi:10.1038/434129a


Science agencies get fresh paymasters in Republican revamp p129

NSF and NASA get new funding bosses in US Congress.

Geoff Brumfiel

doi:10.1038/434129b


news in brief p130

doi:10.1038/434130a


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News Features

Counterfeit pharmaceuticals:  Murder by medicine p132

Across the developing world, people are dying after being peddled fake pharmaceuticals. Peter Aldhous reports from southeast Asia, where scientists, doctors and regulators battle against organized crime.

doi:10.1038/434132a


Counterfeit pharmaceuticals:  In the line of fire p134

Dora Akunyili has spent the past four years facing down corruption and tackling Nigeria's rampant problems with fake drugs. This crusade has been phenomenally successful, but has placed Akunyili's life in danger. Peter Aldhous caught up with her on a recent trip to the United States.

doi:10.1038/434134a


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Correspondence

HIV drug remains unproven without placebo trial p137

Ethical concerns over use of a placebo weaken evidence for the benefits of nevirapine.

Valendar F. Turner

doi:10.1038/434137a


Concern over deep-sea reefs is widespread p137

Alex David Rogers

doi:10.1038/434137b


Brown knew particles were smaller than pollen p137

David M. Wilkinson

doi:10.1038/434137c


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Books and Arts

A part of but apart from politics p139

Can scientists advise policy-makers without compromising their objectivity?

Roger Pielke, Jr reviews Nature's Experts: Science, Politics, and the Environment by Stephen Bocking

doi:10.1038/434139a


Marketing Marie p140

Susan Lindee reviews Obsessive Genius: The Inner World of Marie Curie by Barbara Goldsmith

doi:10.1038/434140a


Science in culture p141

The artist Joseph Beuys tried to lead his followers into a promised land of transformative imagination.

Martin Kemp reviews

doi:10.1038/434141a


Rivalry and revenge p142

Nicola Nosengo reviews Costantinopoli 1786: la congiura e la beffa (Constantinople 1786: The Conspiracy and the Hoax) by Paolo Mazzarello

doi:10.1038/434142a


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Physics detective

Schrödinger's mousetrap p143

Part 8: The outcast.

Jack Cohen

doi:10.1038/434143a


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Essay

Concept

Eggs alone p145

Human parthenotes: an ethical source of stem cells for therapies?

Ann A. Kiessling

doi:10.1038/434145a


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News and Views

Biodiversity:  Fossils make waves p147

A 62-million-year cycle in biodiversity emerges from scrutiny of a marine-fossil database, but its causes remain mysterious. Thus, this discovery is likely to provoke a flurry of theoretical speculation.

James W. Kirchner and Anne Weil

doi:10.1038/434147a

See also: Editor's summary


Astronomy:  Stellar mass limited p148

Is there an upper limit to the mass of a star? The answer to this long-standing question seems to be yes — and it has important consequences for our understanding of the evolution of galaxies.

Pavel Kroupa

doi:10.1038/434148a

See also: Editor's summary


100 and 50 years ago p149

doi:10.1038/434149a


Epigenetics:  Surveillance team against cancer p150

Variations in the control of a phenomenon known as parental imprinting influence the likelihood of tumour development. These new findings may tie in with an earlier concept of 'two-phase' carcinogenesis.

George Klein

doi:10.1038/434150a


Semiconductor technology:  Negatively successful p151

Organic semiconducting polymers are promising electronic materials, but for full versatility they need to conduct negative as well as positive charge. A step towards that goal has now been taken.

Ananth Dodabalapur

doi:10.1038/434151a

See also: Editor's summary


Structural biology:  Methanol maker p151

Joshua Finkelstein

doi:10.1038/434151b


Developmental biology:  Sperm–egg fusion unscrambled p152

The identity of the sperm molecules that are involved in fusion with an egg's membrane has eluded biologists. Will Izumo, a protein named after the Japanese shrine to marriage, bring harmony to the field?

Richard Schultz and Carmen Williams

doi:10.1038/434152a


Planetary sciences:  A smashing pair p153

The likely origin of Pluto and its satellite Charon, like the Earth and Moon, is an impact between two planet-sized bodies. Refined simulations show that there may be two distinct modes for the birth of such twins.

Jay Melosh

doi:10.1038/434153a


Animal behaviour:  Meals sized up p154

Rory Howlett

doi:10.1038/434154a


Palaeobiology:  Dating earliest life p155

Claims that 3.8-billion-year-old rocks from Greenland contain carbonaceous remnants of very early life have been the subject of argument for several years. The latest analyses look like settling matters.

Stephen Moorbath

doi:10.1038/434155a


Research highlights p156

doi:10.1038/434156a


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Brief Communications

Planetary science:  Meteor Crater formed by low-velocity impact p157

The paucity of melted rock in this crater may be due to the striking projectile's speed.

H. J. Melosh and G. S. Collins

doi:10.1038/434157a


Musical imagery:  Sound of silence activates auditory cortex p158

David J. M. Kraemer, C. Neil Macrae, Adam E. Green and William M. Kelley

doi:10.1038/434158a


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Articles

Imaging of Titan from the Cassini spacecraft p159

Carolyn C. Porco, Emily Baker, John Barbara, Kevin Beurle, Andre Brahic, Joseph A. Burns, Sebastien Charnoz, Nick Cooper, Douglas D. Dawson, Anthony D. Del Genio, Tilmann Denk, Luke Dones, Ulyana Dyudina, Michael W. Evans, Stephanie Fussner, Bernd Giese, Kevin Grazier, Paul Helfenstein, Andrew P. Ingersoll, Robert A. Jacobson, Torrence V. Johnson, Alfred McEwen, Carl D. Murray, Gerhard Neukum, William M. Owen, Jason Perry, Thomas Roatsch, Joseph Spitale, Steven Squyres, Peter Thomas, Matthew Tiscareno, Elizabeth P. Turtle, Ashwin R. Vasavada, Joseph Veverka, Roland Wagner and Robert West

doi:10.1038/nature03436

See also: Editor's summary


Experimental one-way quantum computing p169

P. Walther, K. J. Resch, T. Rudolph, E. Schenck, H. Weinfurter, V. Vedral, M. Aspelmeyer and A. Zeilinger

doi:10.1038/nature03347

See also: Editor's summary


Crystal structure of a membrane-bound metalloenzyme that catalyses the biological oxidation of methane p177

Raquel L. Lieberman and Amy C. Rosenzweig

doi:10.1038/nature03311

See also: Editor's summary


Structural basis of HutP-mediated anti-termination and roles of the Mg2+ ion and L-histidine ligand p183

Thirumananseri Kumarevel, Hiroshi Mizuno and Penmetcha K. R. Kumar

doi:10.1038/nature03355


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Letters to Nature

An upper limit to the masses of stars p192

Donald F. Figer

doi:10.1038/nature03293

See also: Editor's summary | News and Views by Kroupa


General observation of n-type field-effect behaviour in organic semiconductors p194

Lay-Lay Chua, Jana Zaumseil, Jui-Fen Chang, Eric C.-W. Ou, Peter K.-H. Ho, Henning Sirringhaus and Richard H. Friend

doi:10.1038/nature03376

See also: News and Views by Dodabalapur


Ultrafast memory loss and energy redistribution in the hydrogen bond network of liquid H2O p199

M. L. Cowan, B. D. Bruner, N. Huse, J. R. Dwyer, B. Chugh, E. T. J. Nibbering, T. Elsaesser and R. J. D. Miller

doi:10.1038/nature03383

See also: Editor's summary


The formation of cubic ice under conditions relevant to Earth's atmosphere p202

Benjamin J. Murray, Daniel A. Knopf and Allan K. Bertram

doi:10.1038/nature03403


Measuring the onset of locking in the Peru–Chile trench with GPS and acoustic measurements p205

Katie Gagnon, C. David Chadwell and Edmundo Norabuena

doi:10.1038/nature03412


Cycles in fossil diversity p208

Robert A. Rohde and Richard A. Muller

doi:10.1038/nature03339

See also: Editor's summary | News and Views by Kirchner & Weil


Agricultural runoff fuels large phytoplankton blooms in vulnerable areas of the ocean p211

J. Michael Beman, Kevin R. Arrigo and Pamela A. Matson

doi:10.1038/nature03370

See also: Editor's summary


The global distribution of clinical episodes of Plasmodium falciparum malaria p214

Robert W. Snow, Carlos A. Guerra, Abdisalan M. Noor, Hla Y. Myint and Simon I. Hay

doi:10.1038/nature03342

See also: Editor's summary


Mediation of pathogen resistance by exudation of antimicrobials from roots p217

Harsh P. Bais, Balakrishnan Prithiviraj, Ajay K. Jha, Frederick M. Ausubel and Jorge M. Vivanco

doi:10.1038/nature03356


Spike-timing-dependent synaptic plasticity depends on dendritic location p221

Robert C. Froemke, Mu-ming Poo and Yang Dan

doi:10.1038/nature03366


The receptors and coding logic for bitter taste p225

Ken L. Mueller, Mark A. Hoon, Isolde Erlenbach, Jayaram Chandrashekar, Charles S. Zuker and Nicholas J. P. Ryba

doi:10.1038/nature03352

See also: Editor's summary


Spatial bistability of Dpp–receptor interactions during Drosophila dorsal–ventral patterning p229

Yu-Chiun Wang and Edwin L. Ferguson

doi:10.1038/nature03318


The immunoglobulin superfamily protein Izumo is required for sperm to fuse with eggs p234

Naokazu Inoue, Masahito Ikawa, Ayako Isotani and Masaru Okabe

doi:10.1038/nature03362

See also: Editor's summary | News and Views by Schultz & Williams


Agonist/endogenous peptide–MHC heterodimers drive T cell activation and sensitivity p238

Michelle Krogsgaard, Qi-jing Li, Cenk Sumen, Johannes B. Huppa, Morgan Huse and Mark M. Davis

doi:10.1038/nature03391


Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors p243

Akinori Takaoka, Hideyuki Yanai, Seiji Kondo, Gordon Duncan, Hideo Negishi, Tatsuaki Mizutani, Shin-ichi Kano, Kenya Honda, Yusuke Ohba, Tak W. Mak and Tadatsugu Taniguchi

doi:10.1038/nature03308


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Naturejobs

Prospects

In the picture p251

Paul Smaglik

doi:10.1038/nj7030-251a


Careers and Recruitment

Come together p252

The addition of molecular biology to the existing range of imaging technologies is creating opportunities for scientists of many disciplines. Paul Smaglik lines up the pieces.

Paul Smaglik

doi:10.1038/nj7030-252a


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Futures

A man of the theatre p256

All the world's a stage.

Norman Spinrad

doi:10.1038/434256a


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