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Correspondence
Nature 434, 137 (10 March 2005) | doi:10.1038/434137a; Published online 9 March 2005
HIV drug remains unproven without placebo trial
Valendar F. Turner1
- Department of Health, 189 Royal Street, East Perth, Western Australia 6004, Australia
Abstract
Ethical concerns over use of a placebo weaken evidence for the benefits of nevirapine.
While raising concerns about "standards of record keeping" in the HIVNET 012 trial in Uganda, in your News story "Activists and researchers rally behind AIDS drug for mothers" (Nature 432, 935; 2004), you overlook a greater flaw. None of the available evidence for nevirapine comes from a trial in which it was tested against a placebo.
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