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Nature ${rb.getVolume()}, 113-118 (${dateTool.format("d MMMMMMMMM yyyy",$article.PubDate)}) | doi:10.1038/nature03354;

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Nutrient control of glucose homeostasis through a complex of PGC-1|[alpha]| and SIRT1

Homeostatic mechanisms in mammals respond to hormones and nutrients to maintain blood glucose levels within a narrow range. Caloric restriction causes many changes in glucose metabolism and extends lifespan; however, how this metabolism is connected to the ageing process is largely unknown.

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