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Editorials

Why Harvard needs Summers p1

The head of Harvard University leaves much to be desired in terms of tact and demonstrable respect for those who disagree with him. But the university should stick with him, at least for the time being.

doi:10.1038/434001a


In pursuit of balance p1

Sunbelt states that have boomed economically should eventually earn a larger slice of the research pie.

doi:10.1038/434001b


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News

NIH workers see red over revised rules for conflicts of interest p3

Employees complain revamped ethical guidelines go too far.

Meredith Wadman

doi:10.1038/434003a


Physicists miss out on critical points as magazines vanish p4

Conspiracy theories circulate about issues "lost" on their way to Los Alamos.

Geoff Brumfiel

doi:10.1038/434004a


Fossil finders in tug of war over analysis of hobbit bones p5

Famous Indonesian skeletons given back to original discovery team.

Rex Dalton

doi:10.1038/434005a


France lays plans for premier cancer centre in Toulouse p5

Europe's largest cancer centre to be built on site of massive explosion.

Alison Abbott

doi:10.1038/434005b


Japanese call for more bite in animal rules p6

Activists battle researchers over upcoming animal-welfare law.

David Cyranoski

doi:10.1038/434006a


Agency to bring fast-breeder reactor out of mothballs p6

Japanese nuclear energy prototype back on track after 1995 accident.

Ichiko Fuyuno

doi:10.1038/434006b


Protest letter accuses health agency of biodefence bias p7

US biologists warn that funding patterns threaten public health.

Erika Check

doi:10.1038/434007a


Pasteur researchers win fight to stay in city centre p7

Mediator report says move to commercial zone isn't needed.

Declan Butler

doi:10.1038/434007b


news in brief p8

doi:10.1038/434008a


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News Features

US science policy:  Upstart states p10

The United States has a settled arrangement for distributing its research budget around the country, and the same states have dominated it for decades. But, as Emma Marris discovers in Florida, the have-nots have had enough.

doi:10.1038/434010a


Antiquities fraud:  Reality check p13

They were highly prized artefacts with inscriptions that dated back to biblical times. The only problem was they were fake. Haim Watzman unearths the authentication work that has rocked Israel's archaeology community.

doi:10.1038/434013a

See also: Editor's summary


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Correspondence

How volunteering for an MRI scan changed my life p17

Discovering a serious problem not only causes shock but can have financial implications.

doi:10.1038/434017a


Coping with unsuspected findings in volunteers p17

Michael Phillips

doi:10.1038/434017b


Solid evidence for bubble fusion? p17

Ross Tessien

doi:10.1038/434017c


India must cooperate on tsunami warning system p17

Costas Synolakis

doi:10.1038/434017d


Ethics and ethnoflora p18

Tony Miller and Miranda Morris

doi:10.1038/434018a


Biologists do not pose a threat to deep-sea vents p18

Paul Tyler, Christopher German and Verena Tunnicliffe

doi:10.1038/434018b


Making sure corrections don't vanish online p18

Eun-Hee Shim and Vishwas Parekh

doi:10.1038/434018c


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Commentary

Watching over the world's oceans p19

A quick technological fix is not the best response to the December tsunami.

doi:10.1038/434019a

See also: Editor's summary


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Books and Arts

Primate viewing p21

Chimpanzee behaviour shows remarkable regional variation.

Tetsuro Matsuzawa reviews The Cultured Chimpanzee: Reflections on Cultural Primatology by William McGrew

doi:10.1038/434021a


Science in court p22

Sheila Jasanoff reviews Laws of Men and Laws of Nature: The History of Scientific Expert Testimony in England and America by Tal Golan

doi:10.1038/434022a


Sizing up the world p22

Stephen Senn reviews Measurement Theory and Practice: The World Through Quantification by David J. Hand

doi:10.1038/434022b


Museum:  A medical history p23

doi:10.1038/434023a


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Physics detective

Schrödinger's mousetrap p25

Part 7: Lessons from the past.

Nicola Spaldin

doi:10.1038/434025a


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News and Views

Coupling and cross-presentation p27

Studies of cultured cells have revealed how the immune system may use intercellular pores to convey information that is important in initiating antiviral responses and in limiting the spread of infections.

William R. Heath and Francis R. Carbone

doi:10.1038/434027a


Astronomy:  Blasts from the radio heavens p28

There is no coherent explanation for newly observed salvos of radio waves emanating from a direction near the Galactic Centre. Are they from a new type of stellar object? The search is on for similar radio emitters.

S. R. Kulkarni and E. Sterl Phinney

doi:10.1038/434028a

See also: Editor's summary


Evolutionary biology:  The hydrogenosome's murky past p29

The evolution of specialized cellular powerhouses called hydrogenosomes has long confounded biologists. The discovery that in some cases they have their own genome sheds some much-needed light on the issue.

Michael W. Gray

doi:10.1038/434029a

See also: Editor's summary


Atmospheric chemistry:  The decay of organic aerosols p31

The chemistry of organic aerosols has been somewhat neglected on the assumption that they are eliminated from the atmosphere mainly by rainfall. Laboratory studies indicate that a rethink is called for.

Euripides G. Stephanou

doi:10.1038/434031a


Biodiversity:  An index of intactness p32

The global community is committed to reducing the rate of loss of biodiversity, but how can progress be measured? A novel system to tackle the problem may also identify key factors behind the changes.

Georgina M. Mace

doi:10.1038/434032a

See also: Editor's summary


Sonoluminescence:  Cavitation hots up p33

Gas inside collapsing bubbles can become very hot and, as a result, emit light. It turns out that temperatures of more than 15,000 kelvin can be reached — as hot as the surface of a bright star.

Detlef Lohse

doi:10.1038/434033a

See also: Editor's summary


100 and 50 years ago p33

doi:10.1038/434033b


Cell cycle:  Cyclin guides the way p34

The main enzymes that drive cell division can work on numerous substrates, but how is their specificity ensured? Regulatory subunits show the way, using various tricks to guide enzymes to their targets.

Curt Wittenberg

doi:10.1038/434034a


Correction p35

doi:10.1038/434035a


research highlights p36

doi:10.1038/434036a


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Brief Communications

Physiology:  Postprandial cardiac hypertrophy in pythons p37

This snake can synthesize fresh heart muscle to cope with extra metabolic demand.

Johnnie B. Andersen, Bryan C. Rourke, Vincent J. Caiozzo, Albert F. Bennett and James W. Hicks

doi:10.1038/434037a


Synaesthesia:  When coloured sounds taste sweet p38

Gian Beeli, Michaela Esslen and Lutz Jäncke

doi:10.1038/434038a


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Articles

Quantum computing with realistically noisy devices p39

E. Knill

doi:10.1038/nature03350

See also: Editor's summary


A biodiversity intactness index p45

R. J. Scholes and R. Biggs

doi:10.1038/nature03289

See also: Editor's summary | News and Views by Mace


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Letters to Nature

A powerful bursting radio source towards the Galactic Centre p50

Scott D. Hyman, T. Joseph W. Lazio, Namir E. Kassim, Paul S. Ray, Craig B. Markwardt and Farhad Yusef-Zadeh

doi:10.1038/nature03400

See also: Editor's summary | News and Views by Kulkarni & Phinney


Plasma formation and temperature measurement during single-bubble cavitation p52

David J. Flannigan and Kenneth S. Suslick

doi:10.1038/nature03361

See also: Editor's summary | News and Views by Lohse


Self-directed self-assembly of nanoparticle/copolymer mixtures p55

Yao Lin, Alexander Böker, Jinbo He, Kevin Sill, Hongqi Xiang, Clarissa Abetz, Xuefa Li, Jin Wang, Todd Emrick, Su Long, Qian Wang, Anna Balazs and Thomas P. Russell

doi:10.1038/nature03310


Mesozoic Alpine facies deposition as a result of past latitudinal plate motion p59

Giovanni Muttoni, Elisabetta Erba, Dennis V. Kent and Valerian Bachtadse

doi:10.1038/nature03378


Insolation-driven changes in atmospheric circulation over the past 116,000 years in subtropical Brazil p63

Francisco W. Cruz, Jr, Stephen J. Burns, Ivo Karmann, Warren D. Sharp, Mathias Vuille, Andrea O. Cardoso, José A. Ferrari, Pedro L. Silva Dias and Oduvaldo Viana, Jr

doi:10.1038/nature03365

See also: Editor's summary


Water-rich basalts at mid-ocean-ridge cold spots p66

Marco Ligi, Enrico Bonatti, Anna Cipriani and Luisa Ottolini

doi:10.1038/nature03264


Kin selection and cooperative courtship in wild turkeys p69

Alan H. Krakauer

doi:10.1038/nature03325

See also: Editor's summary


Disruptive coloration and background pattern matching p72

Innes C. Cuthill, Martin Stevens, Jenna Sheppard, Tracey Maddocks, C. Alejandro Párraga and Tom S. Troscianko

doi:10.1038/nature03312


An anaerobic mitochondrion that produces hydrogen p74

Brigitte Boxma, Rob M. de Graaf, Georg W. M. van der Staay, Theo A. van Alen, Guenola Ricard, Toni Gabaldón, Angela H. A. M. van Hoek, Seung Yeo Moon-van der Staay, Werner J. H. Koopman, Jaap J. van Hellemond, Aloysius G. M. Tielens, Thorsten Friedrich, Marten Veenhuis, Martijn A. Huynen and Johannes H. P. Hackstein

doi:10.1038/nature03343

See also: Editor's summary | News and Views by Gray


Image segmentation and lightness perception p79

Barton L. Anderson and Jonathan Winawer

doi:10.1038/nature03271

See also: Editor's summary


Cross-presentation by intercellular peptide transfer through gap junctions p83

Joost Neijssen, Carla Herberts, Jan Wouter Drijfhout, Eric Reits, Lennert Janssen and Jacques Neefjes

doi:10.1038/nature03290

See also: News and Views by Heath & Carbone


CD4+ T-cell help controls CD8+ T-cell memory via TRAIL-mediated activation-induced cell death p88

Edith M. Janssen, Nathalie M. Droin, Edward E. Lemmens, Michael J. Pinkoski, Steven J. Bensinger, Benjamin D. Ehst, Thomas S. Griffith, Douglas R. Green and Stephen P. Schoenberger

doi:10.1038/nature03337


Two pathways converge at CED-10 to mediate actin rearrangement and corpse removal in C. elegans p93

Jason M. Kinchen, Juan Cabello, Doris Klingele, Kelvin Wong, Richard Feichtinger, Heinke Schnabel, Ralf Schnabel and Michael O. Hengartner

doi:10.1038/nature03263


Phospholipase Cbold gamma1 controls surface expression of TRPC3 through an intermolecular PH domain p99

Damian B. van Rossum, Randen L. Patterson, Sumit Sharma, Roxanne K. Barrow, Michael Kornberg, Donald L. Gill and Solomon H. Snyder

doi:10.1038/nature03340


Cyclin specificity in the phosphorylation of cyclin-dependent kinase substrates p104

Mart Loog and David O. Morgan

doi:10.1038/nature03329

See also: News and Views by Wittenberg


Defective DNA single-strand break repair in spinocerebellar ataxia with axonal neuropathy-1 p108

Sherif F. El-Khamisy, Gulam M. Saifi, Michael Weinfeld, Fredrik Johansson, Thomas Helleday, James R. Lupski and Keith W. Caldecott

doi:10.1038/nature03314

See also: Editor's summary


Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1 p113

Joseph T. Rodgers, Carlos Lerin, Wilhelm Haas, Steven P. Gygi, Bruce M. Spiegelman and Pere Puigserver

doi:10.1038/nature03354


Corrigendum : Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body p118

Dae Sung Hwangbo, Boris Gershman, Meng-Ping Tu, Michael Palmer and Marc Tatar

doi:10.1038/nature03446


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Naturejobs

Prospects

Fighting urban myths p119

Paul Smaglik

doi:10.1038/nj7029-119a


Career View

Graduate Journal:  A hard day's night p120

Tobias Langenhan

doi:10.1038/nj7029-120a


Nuts & Bolts p120

Deb Koen

doi:10.1038/nj7029-120b


Movers p120

doi:10.1038/nj7029-120c


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Futures

A modest proposal... p122

...for the perfection of nature.

Vonda N. McIntyre

doi:10.1038/434122a


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