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Nature 433, 815-816 (24 February 2005) | doi:10.1038/433815a; Published online 23 February 2005
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Human immunodeficiency virus: Refolding the envelope
Peter D. Kwong1
Abstract
HIV has evolved to avoid neutralization by human antibodies. New atomic-level details reveal that such evasion involves substantial refolding of its exterior glycoprotein.
A defining feature of HIV is the ability to thrive for a decade or more despite sustained and vigorous immune attack. How does the virus remain able to infect host cells at the same time as evading immune surveillance?
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Peter D. Kwong is at the Vaccine Research Center, National Institutes of Health, 40 Convent Drive, Bethesda, Maryland
20892, USA.
e-mail: Email: pdkwong@nih.gov
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