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Nature 433, 692-694 (17 February 2005) | doi:10.1038/433692a; Published online 16 February 2005
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Gastroenterologist
- Wayne State University
- Detroit, Michigan, USA
Research Fellow
- Beth Israel Deaconess Medical Center
- Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215
Cell biology: Divide and conquer
Michael Hengartner1
Abstract
The discovery that cell death in nematode worms induces fragmentation of mitochondria reveals a new parallel to the death process in mammals, and may shed light on why mitochondria divide in death.
When mammalian cells die by the process of apoptosis, their mitochondria fragment into smaller pieces. Why these power-generating compartments should divide as the cell around them dies, and whether this fragmentation is important for the death process or simply an epiphenomenon, has so far largely remained unclear.
- Michael Hengartner is at the Institute of Molecular Biology, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland.
e-mail: Email: michael.hengartner@molbio.unizh.ch
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