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News and Views
Nature 433, 591-592 (10 February 2005) | doi:10.1038/433591a; Published online 9 February 2005
Cancer: Catalyst of a catalyst
Stephen C. Kowalczykowski1
Abstract
Breast cancers arise when the BRCA2 protein is defective, but what does the normal enzyme do? Studies of a relative of BRCA2 reveal a capacity to initiate the repair of broken DNA by loading a repair protein.
The identification of the human BRCA2 gene was a landmark discovery in the field of breast cancer1. Mutations in this gene result in a dramatically increased predisposition to breast cancer, as well as to other tumour types.
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