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News and Views
Nature 433, 472-473 (3 February 2005) | doi:10.1038/433472a; Published online 2 February 2005
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Senior Computational Scientist
- Argonne National Laboratory
- Argonne, IL, United States
Scientist / Sr. Scientist - Biopharmaceutics
- Syngene International
- Bangalore, Karnataka 560099 India
RNA interference: Methylation mystery
Michael Ronemus1 & Rob Martienssen1
Abstract
Tiny RNA molecules called microRNAs are important in development, and are thought to function by causing the degradation of matching messenger RNAs. That may not be their only mode of action, however.
RNA molecules come in various sizes, ranging from the very long to the very short. The smaller RNAs fall into two major classes: microRNAs (miRNAs), which guide development in an organism by regulating target genes1; and small interfering RNAs (siRNAs), which target viruses, inserted genes and mobile genetic elements — a significant function being defence of the genome2.
- Michael Ronemus and Rob Martienssen are at the Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA.
e-mail: Email: martiens@cshl.edu
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