Access
To read this story in full you will need to login or make a payment (see right).
News and Views
Nature 432, 960-961 (23 December 2004) | doi:10.1038/432960b; Published online 22 December 2004
Open Innovation Challenges
-
Methods of Modeling Adaptation in Populations
The analysis of adaptation with a population is a frequently encountered computational modeling scen...
-
Single-cell Analysis Platform
This Challenge is looking for novel approaches to analyzing changes at a single-cell level. This is...
- More Challenges
- Powered by:
nature jobs
John Innes Centre Project Leader in Plant or Microbial Sciences
- University of East Anglia
- Norwich, NR4 7TJ, UK
Assistant Professor in the Study of Physical Hazards
- University of Cincinnati
- Cincinnati, Ohio, USA
Molecular biology: Hairpins at split ends in DNA
Marjorie A. Oettinger1
Abstract
What do changing colours in corn kernels, mutations in houseflies and the variability of antibodies and of a T cell's antigen receptors in the vertebrate immune system have in common? A great deal, it turns out.
There once would have seemed to be little similarity between the random movement of transposable genetic elements within a fly, or a corn plant, or a flower petal, and the carefully orchestrated events by which antigen-receptor genes are assembled. The jumping of 'transposons' from one site to another in a genome can alter gene expression, giving rise to mutations that are seen as, for example, a colour change.
- Department of Genetics, Harvard Medical School, and the Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
Email: oettinger@frodo.mgh.harvard.edu
To read this story in full you will need to login or make a payment (see right).
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
NEWS AND VIEWS
Research HighlightsNature Structural & Molecular Biology News and Views (01 Jan 2005)
V (D)J recombination Ragtime jumpingNature News and Views (20 Aug 1998)
RESEARCH
Transposition of hAT elements links transposable elements and V(D)J recombinationNature Article (23 Dec 2004)
piggyBac can bypass DNA synthesis during cut and paste transpositionThe EMBO Journal Article (09 Apr 2008)
See all 9 matches for Research