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Nature 432, 958-959 (23 December 2004) | doi:10.1038/432958a; Published online 22 December 2004
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Food Chemist & Bioactive Specialist
- Nestle Research Center
- Lausanne Switzerland
Canada Research Chair (Tier 1) Alfred Bader Chair in Organic Chemistry
- Queens University
- Kingston, ON, Canada
Diabetes: Outfoxing insulin resistance?
Marc Montminy1 & Seung-Hoi Koo1
Abstract
Resistance to insulin predisposes people to diabetes; it is characterized by increased storage of fats and a failure to stop glucose synthesis. The molecular underpinnings of these effects have been uncovered.
Type II diabetes affects some 5% of adults in most developed countries, and a far higher proportion of the population exhibits insulin resistance, a condition that predisposes individuals to diabetes. The mechanisms leading to insulin resistance are unclear, although the abnormal accumulation of certain fats in the liver (hepatic steatosis) is a contributing factor.
- The Salk Institute for Biological Studies, La Jolla, California 92130, USA.
Email: montminy@salk.edu
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RESEARCH
CREB controls hepatic lipid metabolism through nuclear hormone receptor PPAR-γNature Letters to Editor (13 Nov 2003)
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Insulin modulates gluconeogenesis by inhibition of the coactivator TORC2Nature Letters to Editor (20 Sep 2007)
