Modelling how ribavirin improves interferon response rates in hepatitis C virus infection

doi:doi:10.1038/nature03153

From the following article:

Modelling how ribavirin improves interferon response rates in hepatitis C virus infection

Narendra M. Dixit, Jennifer E. Layden-Almer, Thomas J. Layden and Alan S. Perelson

Nature 432, 922-924(16 December 2004)

doi:10.1038/nature03153

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Supplementary Notes

Contains Supplementary Notes S1–S5, additional comments on the text.

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Supplementary Tables S1–S3

Supplementary Table 1: Best-fit parameter estimates obtained from comparisons of model predictions with experimental viral load data from 17 patients who were given high dose daily interferon along with 1000 or 1200 mg ribavirin daily for the first 28 days of therapy; Supplementary Table 2: Model calculations of end-of-treatment (ETR) and sustained virological responses (SVR) for different initial viral loads, V₀, interferon effectiveness, epsilon , and durations of treatment (24 or 48 weeks), with and without ribavirin; Supplementary Table 3: Estimates of ETR and SVR values as percentages of patients who completed therapy in various studies.