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Nature 432, 862-865 (16 December 2004) | doi:10.1038/nature03197; Published online 15 December 2004
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Professor / Associate Professor (Pharmaceutics / Pharmaceutical Analysis&quality Control)
- Alliance Institute of Advanced Pharmacy and Health Sciences
- Hyderabad 500038 India
Assistant or Associate Professor, Section of Anatomic Pathology
- The Medical College of Georgia
- Augusta, Georgia, USA
commentary Virtual screening of chemical libraries
Brian K. Shoichet1
Abstract
Virtual screening uses computer-based methods to discover new ligands on the basis of biological structures. Although widely heralded in the 1970s and 1980s, the technique has since struggled to meet its initial promise, and drug discovery remains dominated by empirical screening. Recent successes in predicting new ligands and their receptor-bound structures, and better rates of ligand discovery compared to empirical screening, have re-ignited interest in virtual screening, which is now widely used in drug discovery, albeit on a more limited scale than empirical screening.
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