FIGURE 2. Comparison of theoretical viral load decay profiles with patient data.

From the following article:

Modelling how ribavirin improves interferon response rates in hepatitis C virus infection

Narendra M. Dixit, Jennifer E. Layden-Almer, Thomas J. Layden and Alan S. Perelson

Nature 432, 922-924(16 December 2004)

doi:10.1038/nature03153

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Best-fit model predictions (representative) of viral load decay with rhomax = 1 (solid lines) and rhomax = 0 (dashed lines) compared with data (symbols) from patients 18 (a) and 35 (b)23. Parameters employed (Supplementary Table S1) were V0 = 8 times 106 ml-1, c = 3.8 d-1, delta = 0.24 d-1, alt epsilon = 0.982 and tau = 4.3 h for both rhomax = 1 and rhomax = 0 (a) and V0 = 3.6 times 105 ml-1, c = 2.2 d-1, delta = 0.16 d-1, alt epsilon = 0.6 and tau = 6.2 h for rhomax = 1, and V0 = 3.5 times 105 ml-1, c = 3.1 d-1, delta = 0.31 d-1, alt epsilon = 0.5 and tau = 7.2 h for rhomax = 0 (b). Note that the two fits overlap in a.

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