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Nature 432, 680-681 (9 December 2004) | doi:10.1038/432680a; Published online 8 December 2004
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Principal Investigators
- CeMM, The Research Center for Molecular Medicine
- Vienna, Austria
Professorship in Agricultural Engineering
- University of Natural Resources and Applied Life Sciences Vienna
- Vienna, Austria
Microbiology: Jekyll or hide?
George A. O'Toole1
Abstract
Many bacteria can adopt different lifestyles: in a free-living state, they are virulent and cause disease; in a surface-attached community, they are less virulent but may go unnoticed. How is this 'decision' made?
In the November issue of Developmental Cell, Goodman and colleagues1 report the identification of a regulatory system in the bacterium Pseudomonas aeruginosa that determines whether it causes disease or lies low and simply persists. This bacterium is of interest to the medical community because of its ability to infect people whose immune system is damaged, who have sustained serious burns or an eye injury, or who suffer from cystic fibrosis.
- George A. O'Toole is in the Department of Microbiology and Immunology, Dartmouth Medical School, Hanover, New Hampshire 03755, USA.
e-mail: Email: georgeo@dartmouth.edu
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