FIGURE 4. Development of multiple tumour types in p53+/-Fbxw7+/- mice.
From the following article:
Fbxw7/Cdc4 is a p53-dependent, haploinsufficient tumour suppressor gene
Jian-Hua Mao, Jesus Perez-losada, Di Wu, Reyno DelRosario, Ryosuke Tsunematsu, Keiichi I. Nakayama, Ken Brown, Sheila Bryson and Allan Balmain
Nature 432, 775-779(9 December 2004)
doi:10.1038/nature03155
a, Lung tumour, adenocarcinoma; b, fibrosarcoma; c, liver tumour, hepatocarcinoma; d, liver tumour, cholangiocarcinoma; e, osteosarcoma; f, ovary, benign granulosa cell tumour; g, ovary, haemangiosarcoma; h, ovary, malignant granulosa cell tumour. Lung adenocarcinoma, hepatocarcinoma and haemangiosarcoma were also found in the irradiated Fbxw7+/- mice (data not shown).
