FIGURE 3. Radiation-induced tumorigenesis in p53-deficient and Fbxw7-deficient mice.
From the following article:
Fbxw7/Cdc4 is a p53-dependent, haploinsufficient tumour suppressor gene
Jian-Hua Mao, Jesus Perez-losada, Di Wu, Reyno DelRosario, Ryosuke Tsunematsu, Keiichi I. Nakayama, Ken Brown, Sheila Bryson and Allan Balmain
Nature 432, 775-779(9 December 2004)
doi:10.1038/nature03155
a, Tumour development in p53-deficient and Fbxw7-deficient mice: wild-type (diamonds; n = 15), Fbxw7+/- (filled squares; n = 12), p53+/- (filled triangles; n = 21), p53+/-Fbxw7+/- (crosses; n = 23), p53-/- (open circles; n = 13) and p53-/-Fbxw7+/- (plain line; n = 16). b, Most tumours from Fbxw7+/- mice do not show loss of the wild-type allele of Fbxw7: T, tumour DNA; N, normal tail DNA. Tumours 1 and 3 show loss of the Cdc4 wild-type allele, but retention is seen in most cases. c, Continued expression of Fbxw7 RNA (by RT–PCR) in tumours from Fbxw7 heterozygous mouse tumours that did not show LOH.
