FIGURE 1. LOH and mutation analysis of radiation-induced lymphoma.
From the following article:
Fbxw7/Cdc4 is a p53-dependent, haploinsufficient tumour suppressor gene
Jian-Hua Mao, Jesus Perez-losada, Di Wu, Reyno DelRosario, Ryosuke Tsunematsu, Keiichi I. Nakayama, Ken Brown, Sheila Bryson and Allan Balmain
Nature 432, 775-779(9 December 2004)
doi:10.1038/nature03155
a, Frequency of allelic deletion or imbalance on each mouse chromosome: black bars, F1 p53+/- (n = 35); hatched bars, F1 backcross p53+/- (n = 49); F1 backcross p53-/- (n = 61). b, Detailed sub-localization of deletions on chromosome 3 (chr. 3). Physical mapping of markers and genes, and human homology, is based on the Celera database. Tumour numbers 1–5 are from (M. spretus 
129/Sv) hybrids, and tumour numbers 6–9 are from (C57BL/6J 129/Sv) hybrids. Black bar on chromosome shows common deletion region. Tumour 6 showed clear LOH with the marker D3MA44 within the Fbxw7 gene but not at D3MA50 and D3MA57, whereas tumours 7–9 had LOH at D3MA44 but not at D3MA57. Mb, megabases. c, Sequence traces showing the mutations of Fbxw7. Codon positions in Fbxw7
are shown at the left.
