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From the following article:

Mast cells promote homeostasis by limiting endothelin-1-induced toxicity

Marcus Maurer, Jochen Wedemeyer, Martin Metz, Adrian M. Piliponsky, Karsten Weller, Devavani Chatterjea, David E. Clouthier, Masashi M. Yanagisawa, Mindy Tsai and Stephen J. Galli

Nature 432, 512-516(25 November 2004)

doi:10.1038/nature03085

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Figure 1 - Unfortunately we are unable to provide accessible alternative text for this. If you require assistance to access this image, or to obtain a text description, please contact npg@nature.com

Figure 1

Mast cells protect mice from morbidity and mortality after the i.p. injection of ET-1.

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Figure 2

Chymase contributes to the ability of mast cells to degrade ET-1 in vitro and in vivo.

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Figure 3

Genetic evidence that ETA expression contributes to the ability of PMCs to degranulate and to reduce the levels and toxicity of ET-1 in vivo.

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Figure 4

Mast-cell expression of ETA promotes survival in CLP.

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