Supplementary information
From the following article:
Regulation of p53 activity through lysine methylation
Sergei Chuikov, Julia K. Kurash, Jonathan R. Wilson, Bing Xiao, Neil Justin, Gleb S. Ivanov, Kristine McKinney, Paul Tempst, Carol Prives, Steven J. Gamblin, Nickolai A. Barlev and Danny Reinberg
Nature 432, 353-360(18 November 2004)
doi:10.1038/nature03117
Supplementary Figure S1
Set 9 mono-methylates p53. p53 10 mer peptide was methylated by Set9 (52-366aa).
Supplementary Figure S2
Overlay of cartoon representations of Set9 ternary structures with p53 substrate.
Supplementary Figure S3
Set 9 regulates expression of BAX and MDM2 genes.
Supplementary Figure S4
Set9 mediated activation of p21 gene expression requires p53. H1299 cells were stably transfected with Flag-Set9 wt or control vector.
Supplementary Figure S5
Set9 facilitates apoptosis in p53-dependent manner.
Supplementary Table S1
Data and refinement statistics for the ternary complex of SET9 with p53(369-374).
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