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Nature 432, 396-401 (18 November 2004) | doi:10.1038/nature03128;
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Identification of human brain tumour initiating cells
The cancer stem cell (CSC) hypothesis suggests that neoplastic clones are maintained exclusively by a rare fraction of cells with stem cell properties. Although the existence of CSCs in human leukaemia is established, little evidence exists for CSCs in solid tumours, except for breast cancer.
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