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Editorials

Burning issues p131

The Kyoto Protocol is just a small first step in restricting man's influence on climate. If we can't prevent fires in Indonesia, such international efforts to limit the effects of climate change could be in vain.

doi:10.1038/432131a


The stem-cell state p131

California's citizens have changed the landscape of a key area of biology — with intriguing implications for everyone else.

doi:10.1038/432131b


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News

Watchdogs call academies to account over conflicts of interest p133

Coal-mining committee accused of unhealthy ties to industry.

Tony Reichhardt

doi:10.1038/432133a


Trust gives warm welcome to open access p134

Wellcome Trust endorses public archive for biomedical research.

Jim Giles

doi:10.1038/432134a


Leukaemia sleuths accuse state of nuclear cover-up p134

German cancer commission members resign in protest over 'secret lab'.

Barbara Simm

doi:10.1038/432134b


Joys match fears as California agrees to stem-cell proposal p135

State programme bypasses federal opposition to research.

Jonathan Knight

doi:10.1038/432135a


Bush set to keep core science team for second term p135

US President's line-up of science advisers shapes up.

Emma Marris

doi:10.1038/432135b


Herbicide critic dropped from pollution conference p136

Biologist accuses officials of censorship for cancelling his talk.

Rex Dalton

doi:10.1038/432136a


Hopes rise for RNA therapy as mouse study hits target p136

Safety concerns eased for promising medical technique.

Erika Check

doi:10.1038/432136b


Creative Commons ponders share options p137

Alternative licensing scheme for scientists set to launch.

Paula Gould

doi:10.1038/432137a


WHO seeks system for tracking global clinical trials p137

Groundswell of support seen for easy-access register of medical data.

Erika Check

doi:10.1038/432137b


News in brief p138

doi:10.1038/432138a


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News Features

Zoology: A mole in hand... p142

A strange Australian mole has eluded scientific study for more than a century. Now biologists are teaming up with Aboriginal trackers to unearth the secrets of the itjaritjari. Carina Dennis checks on their progress.

Carina Dennis

doi:10.1038/432142a


Land remediation: Borneo is burning p144

Vast tracts of Indonesia's peat swamps have been drained in a misguided attempt to turn them into rice plantations. Now the landscape burns every year, belching smoke and hastening global warming. Peter Aldhous investigates.

Peter Aldhous

doi:10.1038/432144a


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Correspondence

Linear models can't keep up with sport gender gap p147

Will women runners ever overtake men at the Olympics? Don't hold your breath.

Weia Reinboud

doi:10.1038/432147a


Sprint research runs into a credibility gap p147

Kenneth Rice

doi:10.1038/432147b


Biology students find holes in gap study p147

Advanced Placement Biology Class

doi:10.1038/432147c


Mind the gap: women racers are falling behind p147

N. C. Craig Sharp

doi:10.1038/432147d


Mind the gap: women racers are falling behind p147

doi:10.1038/432147e


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Books and Arts

The science of life and death p149

A look at the development of biological weapons and the threat they carry.

doi:10.1038/432149a


The view from Budapest p150

doi:10.1038/432150a


The art of seeing science p151

doi:10.1038/432151a


Film:  The story of life p151

Federica Castellani

doi:10.1038/432151b


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Essay

Turning points

Making waves p153

How a stroll in the park led to the beginning of quantum electronics.

Charles H. Townes

doi:10.1038/432153a


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News and Views

医学:RNA干渉法でコレステロール値を下げる

Medicine:  A cholesterol connection in RNAi p155

RNA interference — RNAi for short — might provide a way to silence disease-associated genes, but problems of delivery have hampered progress. Those problems may have been solved, at least in animal studies.

John J. Rossi

doi:10.1038/432155a


地球科学:砂漠の化石からマントルの形を探る

Earth science:  Mantle mapped in the desert p156

How does variation in ocean-floor rocks arise from differences in the temperature of their mantle source? A new angle on the question comes from painstaking work on one of the geological wonders of the world.

Georges Ceuleneer

doi:10.1038/432156a


DNA 修復:大きな装置で小さな亀裂を直す

DNA repair:  Big engine finds small breaks p157

When a break occurs in the DNA double helix, it must be dealt with rapidly. The structure of one of the cellular machines responsible is now revealed, offering insights into its impressive speed and flexibility.

Anna Marie Pyle

doi:10.1038/432157a


生態学:高いところはツンドラの安全地帯

Ecology:  Hope in the hills for tundra? p159

Will global warming cause northern forests to spread into arctic tundra? A study of black spruce suggests that the answer is complex and varies according to latitude and altitude.

Peter D. Moore

doi:10.1038/432159a


動物行動:ランキングの罪と罰

100 and 50 years ago p160

doi:10.1038/432160a


Animal behaviour:  Rank crime and punishment p160

In paper wasps, facial markings are cheap 'status badges' that would seem to be susceptible to cheating. But wasps punish those whose markings lie. Social competition is, it appears, a strong selective force.

Joan E. Strassmann

doi:10.1038/432160b


植物の発生:花束が葉束に変わる時

Plant development:  A bunch of leaves p161

Christopher Surridge

doi:10.1038/432161a


物性物理学:磁気の振り子

Condensed-matter physics:  A magnetic pendulum p162

Where two oppositely magnetized regions meet, there is a so-called domain wall. Under the right conditions, this wall can be made to oscillate like a pendulum, suggesting a new approach to electronics.

Claude Chappert and Thibaut Devolder

doi:10.1038/432162a


Research highlights p163

doi:10.1038/432163a


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Brief Communications

Laser beams:  Knotted threads of darkness p165

Dark lines within a laser beam can be manipulated to form stable vortex knots.

Jonathan Leach, Mark R. Dennis, Johannes Courtial and Miles J. Padgett

doi:10.1038/432165a


Plant genetics:  Gene transfer from parasitic to host plants p165

Jeffrey P. Mower, Sas carona Stefanovic acute, Gregory J. Young and Jeffrey D. Palmer

doi:10.1038/432165b


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Brief Communications Arising

Evolution:  How do characters evolve?

Andy Purvis

doi:10.1038/nature03092


Evolution:  How do characters evolve? (reply)

Robert E. Ricklefs

doi:10.1038/nature03093


Top

Articles

地球:オマーンオフィオライトの過去の大洋中央海嶺に沿ったマントルの分割

Mantle segmentation along the Oman ophiolite fossil mid-ocean ridge p167

Laurent Le Mée, Jacques Girardeau and Christophe Monnier

doi:10.1038/nature03075


医学:修飾型siRNAの全身投与によって内在性遺伝子を抑制する治療

Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs p173

Jürgen Soutschek, Akin Akinc, Birgit Bramlage, Klaus Charisse, Rainer Constien, Mary Donoghue, Sayda Elbashir, Anke Geick, Philipp Hadwiger, Jens Harborth, Matthias John, Venkitasamy Kesavan, Gary Lavine, Rajendra K. Pandey, Timothy Racie, Kallanthottathil G. Rajeev, Ingo Röhl, Ivanka Toudjarska, Gang Wang, Silvio Wuschko, David Bumcrot, Victor Koteliansky, Stefan Limmer, Muthiah Manoharan and Hans-Peter Vornlocher

doi:10.1038/nature03121


発生:ネトリン受容体UNC5Bが血管系の形態形成を制御するガイダンス現象にかかわる

The netrin receptor UNC5B mediates guidance events controlling morphogenesis of the vascular system p179

Xiaowei Lu, Ferdinand le Noble, Li Yuan, Quingjan Jiang, Benjamin de Lafarge, Daisuke Sugiyama, Christiane Bréant, Filip Claes, Frederik De Smet, Jean-Léon Thomas, Monica Autiero, Peter Carmeliet, Marc Tessier-Lavigne and Anne Eichmann

doi:10.1038/nature03080


生化学:RecBCD酵素の結晶構造により明らかになるDNA切断処理機構

Crystal structure of RecBCD enzyme reveals a machine for processing DNA breaks p187

Martin R. Singleton, Mark S. Dillingham, Martin Gaudier, Stephen C. Kowalczykowski and Dale B. Wigley

doi:10.1038/nature02988


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Letters to Nature

宇宙:宇宙再電離の末期における電離したバブルに特徴的なおよそ10 Mpcの大きさ

A characteristic size of approx10 Mpc for the ionized bubbles at the end of cosmic reionization p194

J. Stuart B. Wyithe and Abraham Loeb

doi:10.1038/nature03033


物理:単一量子ドット−半導体微小共振器系における強い結合

Strong coupling in a single quantum dot–semiconductor microcavity system p197

J. P. Reithmaier, G. Se ogonk, A. Löffler, C. Hofmann, S. Kuhn, S. Reitzenstein, L. V. Keldysh, V. D. Kulakovskii, T. L. Reinecke and A. Forchel

doi:10.1038/nature02969


物理:フォトニック結晶光ナノ共振器における単一量子ドットの真空ラビ分裂

Vacuum Rabi splitting with a single quantum dot in a photonic crystal nanocavity p200

T. Yoshie, A. Scherer, J. Hendrickson, G. Khitrova, H. M. Gibbs, G. Rupper, C. Ell, O. B. Shchekin and D. G. Deppe

doi:10.1038/nature03119


物性:単一磁壁の電流誘起共鳴と質量決定

Current-induced resonance and mass determination of a single magnetic domain wall p203

Eiji Saitoh, Hideki Miyajima, Takehiro Yamaoka and Gen Tatara

doi:10.1038/nature03009


光学:結合したマイクロリングレーザーを使った高速低電力光メモリ

A fast low-power optical memory based on coupled micro-ring lasers p206

Martin T. Hill, Harmen J. S. Dorren, Tjibbe de Vries, Xaveer J. M. Leijtens, Jan Hendrik den Besten, Barry Smalbrugge, Yok-Siang Oei, Hans Binsma, Giok-Djan Khoe and Meint K. Smit

doi:10.1038/nature03045


惑星:もっとも若い年代の月の火成岩から示される月のKREEP火成活動の延長

Prolonged KREEP magmatism on the Moon indicated by the youngest dated lunar igneous rock p209

Lars E. Borg, Charles K. Shearer, Yemane Asmerom and James J. Papike

doi:10.1038/nature03070


進化:哺乳類の歯の特徴は互いに独立性がない

Nonindependence of mammalian dental characters p211

Aapo T. Kangas, Alistair R. Evans, Irma Thesleff and Jukka Jernvall

doi:10.1038/nature02927


進化:有蹄類では性選択が老化の「使い捨ての体」説に関与する

Disposable-soma senescence mediated by sexual selection in an ungulate p215

Juan Carranza, Susana Alarcos, Cristina B. Sánchez-Prieto, Juliana Valencia and Concha Mateos

doi:10.1038/nature03004


生態:アシナガバチの一種では質を伝えるシグナルが社会的に施行される

A socially enforced signal of quality in a paper wasp p218

Elizabeth A. Tibbetts and James Dale

doi:10.1038/nature02949


生態:ジャガイモの多様性中心地における環境生物安全性と遺伝子組換えジャガイモ

Environmental biosafety and transgenic potato in a centre of diversity for this crop p222

Carolina Celis, Maria Scurrah, Sue Cowgill, Susana Chumbiauca, Jayne Green, Javier Franco, Gladys Main, Daan Kiezebrink, Richard G. F. Visser and Howard J. Atkinson

doi:10.1038/nature03048


生理:膵島に特異的なマイクロRNAがインスリン分泌を制御する

A pancreatic islet-specific microRNA regulates insulin secretion p226

Matthew N. Poy, Lena Eliasson, Jan Krutzfeldt, Satoru Kuwajima, Xiaosong Ma, Patrick E. MacDonald, Sébastien Pfeffer, Thomas Tuschl, Nikolaus Rajewsky, Patrik Rorsman and Markus Stoffel

doi:10.1038/nature03076


生化学:マイクロプロセッサー複合体による一次マイクロRNAのプロセシング

Processing of primary microRNAs by the Microprocessor complex p231

Ahmet M. Denli, Bastiaan B. J. Tops, Ronald H. A. Plasterk, René F. Ketting and Gregory J. Hannon

doi:10.1038/nature03049


生化学:マイクロRNAの生成にはマイクロプロセッサー複合体が関与する

The Microprocessor complex mediates the genesis of microRNAs p235

Richard I. Gregory, Kai-ping Yan, Govindasamy Amuthan, Thimmaiah Chendrimada, Behzad Doratotaj, Neil Cooch and Ramin Shiekhattar

doi:10.1038/nature03120


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Technology Features

Cell signalling:  Making connections p243

Technological innovations in detecting and studying protein–protein interactions are providing new ways of doing research in cell signalling. Diane Gershon investigates.

Diane Gershon

doi:10.1038/432243a


In the market-place p243

doi:10.1038/432243b


Quantum dots show their true colours p247

doi:10.1038/432247a


Probing real-time protein interactions p249

doi:10.1038/432249a


Table of suppliers p250

doi:10.1038/432250a


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Naturejobs

Prospects

The secrets of success p253

Paul Smaglik

doi:10.1038/nj7014-253a


Special Report

Getting on the fast-track to full-time employment p254

The road to your first full-time position can be long and tortuous. But some researchers have found a shortcut to success. Eugene Russo reports.

Eugene Russo

doi:10.1038/nj7014-254a


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